DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
ISTPRPS
Uniprot ID:
Q5R372
Source protein:
Rab GTPase-activating protein 1-like
Source gene:
RABGAP1L
Class:
DEG_SCF_FBW7_1
Location:
112:118
E3 ligase:
FBXW7
DEGRON score:
0.6923
ASA_SCORE:
91.3429
COIL:
0.9549
CONS_SCORE:
0.27
DSS_SCORE:
0.7214
HELIX:
0.0149
FCONS_SCORE:
1.0069
RIG_SCORE:
0.6085
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RABGAP1L mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ISTPRPS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5R372
Rab GTPase-activating protein 1-like
DEG_SCF_FBW7_1
112:118
ISTPRPS
FBXW7
0.6923
More...