DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ISVFRE
Uniprot ID:
A6NFK2
Source protein:
Glutaredoxin domain-containing cysteine-rich protein 2
Source gene:
GRXCR2
Class:
LIG_APCC_ABBA_1
Location:
85:90
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6791
ASA_SCORE:
75.7833
COIL:
0.389
CONS_SCORE:
0.5377
DSS_SCORE:
0.3316
HELIX:
0.0672
FCONS_SCORE:
1.1071
RIG_SCORE:
0.8216
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P78S
DO218849
SKCA
ICGC
ISVFRE
LIG_APCC_ABBA_1
0.1389
p.G98D
DO234285
ESAD
ICGC
ISVFRE
LIG_APCC_ABBA_1
0.1111
p.S77F
DO229502
SKCA
ICGC
ISVFRE
LIG_APCC_ABBA_1
0.1111
p.G98C
SIDM00061
Ovarian Carcinoma
GDSC
ISVFRE
LIG_APCC_ABBA_1
0.1111
p.G98C
SIDM01095
Rhabdomyosarcoma
GDSC
ISVFRE
LIG_APCC_ABBA_1
0.1111
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Drug responses associated with GRXCR2 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of ISVFRE
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NFK2
Glutaredoxin domain-containing cysteine-rich protein 2
LIG_APCC_ABBA_1
85:90
ISVFRE
APC,CDC20,FZR1
0.6791
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