DegronMD

Uniprot ID: A6NFK2

Source protein: Glutaredoxin domain-containing cysteine-rich protein 2

Source gene: GRXCR2

Class: LIG_APCC_ABBA_1

Location: 85:90

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6791

ASA_SCORE: 75.7833

COIL: 0.389

CONS_SCORE: 0.5377

DSS_SCORE: 0.3316

HELIX: 0.0672

FCONS_SCORE: 1.1071

RIG_SCORE: 0.8216

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G98D	DO234285	ESAD	ICGC	ISVFRE	LIG_APCC_ABBA_1	0.1111
p.P78S	DO218849	SKCA	ICGC	ISVFRE	LIG_APCC_ABBA_1	0.1389
p.S77F	DO229502	SKCA	ICGC	ISVFRE	LIG_APCC_ABBA_1	0.1111
p.G98C	SIDM00061	Ovarian Carcinoma	GDSC	ISVFRE	LIG_APCC_ABBA_1	0.1111
p.G98C	SIDM01095	Rhabdomyosarcoma	GDSC	ISVFRE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NFK2	Glutaredoxin domain-containing cysteine-rich protein 2	LIG_APCC_ABBA_1	85:90	ISVFRE	APC,CDC20,FZR1	0.6791	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons