DegronMD

Uniprot ID: Q7Z6E9

Source protein: E3 ubiquitin-protein ligase RBBP6

Source gene: RBBP6

Class: LIG_APCC_ABBA_1

Location: 418:423

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9639

ASA_SCORE: 99.45

COIL: 0.9367

CONS_SCORE: 0.3469

DSS_SCORE: 0.5126

HELIX: 0.0423

FCONS_SCORE: 1.1417

RIG_SCORE: 0.6984

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V416L	DO229005	COCA	ICGC	ISVHSE	LIG_APCC_ABBA_1	0.2778
p.V416L	DO35100	PACA	ICGC	ISVHSE	LIG_APCC_ABBA_1	0.2778
p.V416A	ACH-001610	Brain Cancer	CCLE	ISVHSE	LIG_APCC_ABBA_1	0.2778
p.P428R	SIDM00853	Other Sarcomas	GDSC	ISVHSE	LIG_APCC_ABBA_1	0.1944
p.P428R	ACH-000835	Sarcoma	CCLE	ISVHSE	LIG_APCC_ABBA_1	0.1944
p.P428R	GCT	soft_tissue	COSMIC	ISVHSE	LIG_APCC_ABBA_1	0.1944
p.R430W	TCGA-44-8119	LUAD	TCGA	ISVHSE	LIG_APCC_ABBA_1	0.1389
p.R430W	TCGA-GN-A266	SKCM	TCGA	ISVHSE	LIG_APCC_ABBA_1	0.1389
p.R430W	DO24399	LUAD	ICGC	ISVHSE	LIG_APCC_ABBA_1	0.1389
p.R430W	DO37432	SKCM	ICGC	ISVHSE	LIG_APCC_ABBA_1	0.1389
p.V409G	SIDM00434	Plasma Cell Myeloma	GDSC	ISVHSE	LIG_APCC_ABBA_1	0.0833
p.V409G	ACH-000745	Myeloma	CCLE	ISVHSE	LIG_APCC_ABBA_1	0.0833
p.V409G	MOLP-8	haematopoietic_and_lymphoid_tissue	COSMIC	ISVHSE	LIG_APCC_ABBA_1	0.0833

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	LIG_APCC_ABBA_1	418:423	ISVHSE	APC,CDC20,FZR1	0.9639	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons