DegronMD

Uniprot ID: P36578

Source protein: 60S ribosomal protein L4

Source gene: RPL4

Class: LIG_APCC_ABBA_1

Location: 8:13

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8195

ASA_SCORE: 42.6667

COIL: 0.2657

CONS_SCORE: 0.4965

DSS_SCORE: 0.3581

HELIX: 0.0053

FCONS_SCORE: 1.1449

RIG_SCORE: 0.7672

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E13K	TCGA-AA-3715	COAD	TCGA	ISVYSE	LIG_APCC_ABBA_1	0.7022
p.E13K	DO8018	COAD	ICGC	ISVYSE	LIG_APCC_ABBA_1	0.7022
p.S18F	TCGA-BR-A4J9	STAD	TCGA	ISVYSE	LIG_APCC_ABBA_1	0.1944
p.S18F	DO38735	STAD	ICGC	ISVYSE	LIG_APCC_ABBA_1	0.1944
p.A2V	TCGA-CF-A47W	BLCA	TCGA	ISVYSE	LIG_APCC_ABBA_1	0.6111
p.A2V	DO44056	BLCA	ICGC	ISVYSE	LIG_APCC_ABBA_1	0.6111
p.P6S	TCGA-CR-6467	HNSC	TCGA	ISVYSE	LIG_APCC_ABBA_1	0.2778
p.P6S	DO14942	HNSC	ICGC	ISVYSE	LIG_APCC_ABBA_1	0.2778
p.P6Q	TCGA-D9-A1X3	SKCM	TCGA	ISVYSE	LIG_APCC_ABBA_1	0.2778
p.P6Q	DO37456	SKCM	ICGC	ISVYSE	LIG_APCC_ABBA_1	0.2778
p.G15W	TCGA-EE-A2A5	SKCM	TCGA	ISVYSE	LIG_APCC_ABBA_1	0.2778
p.G15W	DO37941	SKCM	ICGC	ISVYSE	LIG_APCC_ABBA_1	0.2778
p.S12F	TCGA-FW-A3R5	SKCM	TCGA	ISVYSE	LIG_APCC_ABBA_1	0.7982
p.S12F	DO37406	SKCM	ICGC	ISVYSE	LIG_APCC_ABBA_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P36578	60S ribosomal protein L4	LIG_APCC_ABBA_1	8:13	ISVYSE	APC,CDC20,FZR1	0.8195	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons