DegronMD - P36578(RPL4)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E254K	TCGA-66-2785	LUSC	TCGA	LAPGGHVGRFCI	DEG_ODPH_VHL_1	240:251	Mutation rewiring degron network	0.25
p.E254K	DO26520	LUSC	ICGC	LAPGGHVGRFCI	DEG_ODPH_VHL_1	240:251	Mutation rewiring degron network	0.25
p.E13K	TCGA-AA-3715	COAD	TCGA	ISVYSE	LIG_APCC_ABBA_1	8:13	Mutation altering degron motif	0.7022
p.E13K	DO8018	COAD	ICGC	ISVYSE	LIG_APCC_ABBA_1	8:13	Mutation altering degron motif	0.7022
p.I237M	TCGA-AJ-A3EK	UCEC	TCGA	LAPGGHVGRFCI	DEG_ODPH_VHL_1	240:251	Mutation rewiring degron network	0.25
p.I237M	DO41584	UCEC	ICGC	LAPGGHVGRFCI	DEG_ODPH_VHL_1	240:251	Mutation rewiring degron network	0.25
p.N236S	TCGA-AX-A2HC	UCEC	TCGA	LAPGGHVGRFCI	DEG_ODPH_VHL_1	240:251	Mutation rewiring degron network	0.2222
p.N236S	DO41572	UCEC	ICGC	LAPGGHVGRFCI	DEG_ODPH_VHL_1	240:251	Mutation rewiring degron network	0.2222
p.S18F	TCGA-BR-A4J9	STAD	TCGA	ISVYSE	LIG_APCC_ABBA_1	8:13	Mutation rewiring degron network	0.1944
p.S18F	DO38735	STAD	ICGC	ISVYSE	LIG_APCC_ABBA_1	8:13	Mutation rewiring degron network	0.1944
p.A2V	TCGA-CF-A47W	BLCA	TCGA	ISVYSE	LIG_APCC_ABBA_1	8:13	Mutation blocking phosphorylation signal	0.6111
p.A2V	DO44056	BLCA	ICGC	ISVYSE	LIG_APCC_ABBA_1	8:13	Mutation blocking phosphorylation signal	0.6111
p.P6S	TCGA-CR-6467	HNSC	TCGA	ISVYSE	LIG_APCC_ABBA_1	8:13	Mutation rewiring degron network	0.2778
p.P6S	DO14942	HNSC	ICGC	ISVYSE	LIG_APCC_ABBA_1	8:13	Mutation rewiring degron network	0.2778
p.P6Q	TCGA-D9-A1X3	SKCM	TCGA	ISVYSE	LIG_APCC_ABBA_1	8:13	Mutation rewiring degron network	0.2778
p.P6Q	DO37456	SKCM	ICGC	ISVYSE	LIG_APCC_ABBA_1	8:13	Mutation rewiring degron network	0.2778
p.G15W	TCGA-EE-A2A5	SKCM	TCGA	ISVYSE	LIG_APCC_ABBA_1	8:13	Mutation rewiring degron network	0.2778
p.G15W	DO37941	SKCM	ICGC	ISVYSE	LIG_APCC_ABBA_1	8:13	Mutation rewiring degron network	0.2778
p.S12F	TCGA-FW-A3R5	SKCM	TCGA	ISVYSE	LIG_APCC_ABBA_1	8:13	Mutation altering degron motif	0.7982
p.S12F	DO37406	SKCM	ICGC	ISVYSE	LIG_APCC_ABBA_1	8:13	Mutation altering degron motif	0.7982
p.L230I	DO222739	ESCA	ICGC	LAPGGHVGRFCI	DEG_ODPH_VHL_1	240:251	Mutation rewiring degron network	0.0556
p.N236K	DO229025	LICA	ICGC	LAPGGHVGRFCI	DEG_ODPH_VHL_1	240:251	Mutation rewiring degron network	0.2222
p.E254D	SIDM00849	Kidney Carcinoma	GDSC	LAPGGHVGRFCI	DEG_ODPH_VHL_1	240:251	Mutation rewiring degron network	0.25
p.C250Y	SIDM00986	Head and Neck Carcinoma	GDSC	LAPGGHVGRFCI	DEG_ODPH_VHL_1	240:251	Mutation altering degron motif	0.5976
p.C250Y	BHY	upper aerodigestive tract	COSMIC	LAPGGHVGRFCI	DEG_ODPH_VHL_1	240:251	Mutation altering degron motif	0.5976
p.N235S	ACH-000990	Endometrial/Uterine Cancer	CCLE	LAPGGHVGRFCI	DEG_ODPH_VHL_1	240:251	Mutation rewiring degron network	0.1944
p.H253L	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	LAPGGHVGRFCI	DEG_ODPH_VHL_1	240:251	Mutation rewiring degron network	0.2778

Kaplan plot for RPL4 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RPL4

UniProt ID: P36578

Entrez ID: 6124

Protein name: 60S ribosomal protein L4 (60S ribosomal protein L1) (Large ribosomal subunit protein uL4)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RPL4 in