DegronMD

Uniprot ID: P36578

Source protein: 60S ribosomal protein L4

Source gene: RPL4

Class: DEG_ODPH_VHL_1

Location: 240:251

E3 ligase: VHL

DEGRON score: 0.7418

ASA_SCORE: 29.55

COIL: 0.5456

CONS_SCORE: 0.8154

DSS_SCORE: 0.0354

HELIX: 0.0874

FCONS_SCORE: 1.2705

RIG_SCORE: 0.8345

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E254K	TCGA-66-2785	LUSC	TCGA	LAPGGHVGRFCI	DEG_ODPH_VHL_1	0.25
p.E254K	DO26520	LUSC	ICGC	LAPGGHVGRFCI	DEG_ODPH_VHL_1	0.25
p.I237M	TCGA-AJ-A3EK	UCEC	TCGA	LAPGGHVGRFCI	DEG_ODPH_VHL_1	0.25
p.I237M	DO41584	UCEC	ICGC	LAPGGHVGRFCI	DEG_ODPH_VHL_1	0.25
p.N236S	TCGA-AX-A2HC	UCEC	TCGA	LAPGGHVGRFCI	DEG_ODPH_VHL_1	0.2222
p.N236S	DO41572	UCEC	ICGC	LAPGGHVGRFCI	DEG_ODPH_VHL_1	0.2222
p.L230I	DO222739	ESCA	ICGC	LAPGGHVGRFCI	DEG_ODPH_VHL_1	0.0556
p.N236K	DO229025	LICA	ICGC	LAPGGHVGRFCI	DEG_ODPH_VHL_1	0.2222
p.E254D	SIDM00849	Kidney Carcinoma	GDSC	LAPGGHVGRFCI	DEG_ODPH_VHL_1	0.25
p.C250Y	SIDM00986	Head and Neck Carcinoma	GDSC	LAPGGHVGRFCI	DEG_ODPH_VHL_1	0.5976
p.C250Y	BHY	upper_aerodigestive_tract	COSMIC	LAPGGHVGRFCI	DEG_ODPH_VHL_1	0.5976
p.N235S	ACH-000990	Endometrial/Uterine Cancer	CCLE	LAPGGHVGRFCI	DEG_ODPH_VHL_1	0.1944
p.H253L	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	LAPGGHVGRFCI	DEG_ODPH_VHL_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P36578	60S ribosomal protein L4	DEG_ODPH_VHL_1	240:251	LAPGGHVGRFCI	VHL	0.7418	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons