DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ITLYED
Uniprot ID:
P07320
Source protein:
Gamma-crystallin D
Source gene:
CRYGD
Class:
LIG_APCC_ABBA_1
Location:
4:9
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5575
ASA_SCORE:
35.2333
COIL:
0.1122
CONS_SCORE:
0.8298
DSS_SCORE:
0.5586
HELIX:
0.0015
FCONS_SCORE:
0.9419
RIG_SCORE:
0.814
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E18K
TCGA-AJ-A3EL
UCEC
TCGA
ITLYED
LIG_APCC_ABBA_1
0.0833
p.E18K
DO41542
UCEC
ICGC
ITLYED
LIG_APCC_ABBA_1
0.0833
p.L6P
TCGA-D3-A1QB
SKCM
TCGA
ITLYED
LIG_APCC_ABBA_1
0.6471
p.L6P
DO47573
SKCM
ICGC
ITLYED
LIG_APCC_ABBA_1
0.6471
p.L6I
TCGA-FS-A1ZZ
SKCM
TCGA
ITLYED
LIG_APCC_ABBA_1
0.6063
p.L6I
DO37412
SKCM
ICGC
ITLYED
LIG_APCC_ABBA_1
0.6063
p.G2W
DO230347
COCA
ICGC
ITLYED
LIG_APCC_ABBA_1
0.2778
p.R15H
DO234372
ESAD
ICGC
ITLYED
LIG_APCC_ABBA_1
0.1667
p.I4M
SIDM01494
Glioblastoma
GDSC
ITLYED
LIG_APCC_ABBA_1
0.6507
p.I4M
ACH-000445
Brain Cancer
CCLE
ITLYED
LIG_APCC_ABBA_1
0.6507
p.R10W
ACH-002659
Colon/Colorectal Cancer
CCLE
ITLYED
LIG_APCC_ABBA_1
0.3056
p.T5P
SU-DHL-10
haematopoietic_and_lymphoid_tissue
COSMIC
ITLYED
LIG_APCC_ABBA_1
0.5919
Drug responses associated with CRYGD mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ITLYED
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P07320
Gamma-crystallin D
LIG_APCC_ABBA_1
4:9
ITLYED
APC,CDC20,FZR1
0.5575
More...