DegronMD - P07320(CRYGD)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E18K	TCGA-AJ-A3EL	UCEC	TCGA	ITLYED	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.0833
p.E18K	TCGA-AJ-A3EL	UCEC	TCGA	KITLYED	LIG_APCC_ABBAyCdc20_2	3:9	Mutation rewiring degron network	0.0833
p.E18K	DO41542	UCEC	ICGC	ITLYED	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.0833
p.E18K	DO41542	UCEC	ICGC	KITLYED	LIG_APCC_ABBAyCdc20_2	3:9	Mutation rewiring degron network	0.0833
p.L6P	TCGA-D3-A1QB	SKCM	TCGA	ITLYED	LIG_APCC_ABBA_1	4:9	Mutation altering degron motif	0.6471
p.L6P	TCGA-D3-A1QB	SKCM	TCGA	KITLYED	LIG_APCC_ABBAyCdc20_2	3:9	Mutation altering degron motif	0.7582
p.L6P	DO47573	SKCM	ICGC	ITLYED	LIG_APCC_ABBA_1	4:9	Mutation altering degron motif	0.6471
p.L6P	DO47573	SKCM	ICGC	KITLYED	LIG_APCC_ABBAyCdc20_2	3:9	Mutation altering degron motif	0.7582
p.L6I	TCGA-FS-A1ZZ	SKCM	TCGA	ITLYED	LIG_APCC_ABBA_1	4:9	Mutation altering degron motif	0.6063
p.L6I	TCGA-FS-A1ZZ	SKCM	TCGA	KITLYED	LIG_APCC_ABBAyCdc20_2	3:9	Mutation altering degron motif	0.6063
p.L6I	DO37412	SKCM	ICGC	ITLYED	LIG_APCC_ABBA_1	4:9	Mutation altering degron motif	0.6063
p.L6I	DO37412	SKCM	ICGC	KITLYED	LIG_APCC_ABBAyCdc20_2	3:9	Mutation altering degron motif	0.6063
p.K3N	DO228276	BRCA	ICGC	KITLYED	LIG_APCC_ABBAyCdc20_2	3:9	Mutation altering degron motif	0.6918
p.G2W	DO230347	COCA	ICGC	ITLYED	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.2778
p.G2W	DO230347	COCA	ICGC	KITLYED	LIG_APCC_ABBAyCdc20_2	3:9	Mutation rewiring degron network	0.3056
p.R15H	DO234372	ESAD	ICGC	ITLYED	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.1667
p.R15H	DO234372	ESAD	ICGC	KITLYED	LIG_APCC_ABBAyCdc20_2	3:9	Mutation rewiring degron network	0.1667
p.I4M	SIDM01494	Glioblastoma	GDSC	ITLYED	LIG_APCC_ABBA_1	4:9	Mutation altering degron motif	0.6507
p.I4M	SIDM01494	Glioblastoma	GDSC	KITLYED	LIG_APCC_ABBAyCdc20_2	3:9	Mutation altering degron motif	0.6507
p.I4M	ACH-000445	Brain Cancer	CCLE	ITLYED	LIG_APCC_ABBA_1	4:9	Mutation altering degron motif	0.6507
p.I4M	ACH-000445	Brain Cancer	CCLE	KITLYED	LIG_APCC_ABBAyCdc20_2	3:9	Mutation altering degron motif	0.6507
p.R10W	ACH-002659	Colon/Colorectal Cancer	CCLE	ITLYED	LIG_APCC_ABBA_1	4:9	Mutation rewiring degron network	0.3056
p.R10W	ACH-002659	Colon/Colorectal Cancer	CCLE	KITLYED	LIG_APCC_ABBAyCdc20_2	3:9	Mutation rewiring degron network	0.3056
p.T5P	SU-DHL-10	haematopoietic and lymphoid tissue	COSMIC	ITLYED	LIG_APCC_ABBA_1	4:9	Mutation altering degron motif	0.5919
p.T5P	SU-DHL-10	haematopoietic and lymphoid tissue	COSMIC	KITLYED	LIG_APCC_ABBAyCdc20_2	3:9	Mutation altering degron motif	0.5919

Kaplan plot for CRYGD in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CRYGD

UniProt ID: P07320

Entrez ID: 1421

Protein name: Gamma-crystallin D (Gamma-D-crystallin) (Gamma-crystallin 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CRYGD in