DegronMD

Uniprot ID: P07320

Source protein: Gamma-crystallin D

Source gene: CRYGD

Class: LIG_APCC_ABBAyCdc20_2

Location: 3:9

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.731

ASA_SCORE: 44.6857

COIL: 0.1831

CONS_SCORE: 0.8314

DSS_SCORE: 0.5859

HELIX: 0.0024

FCONS_SCORE: 0.9406

RIG_SCORE: 0.808

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E18K	TCGA-AJ-A3EL	UCEC	TCGA	KITLYED	LIG_APCC_ABBAyCdc20_2	0.0833
p.E18K	DO41542	UCEC	ICGC	KITLYED	LIG_APCC_ABBAyCdc20_2	0.0833
p.L6P	TCGA-D3-A1QB	SKCM	TCGA	KITLYED	LIG_APCC_ABBAyCdc20_2	0.7582
p.L6P	DO47573	SKCM	ICGC	KITLYED	LIG_APCC_ABBAyCdc20_2	0.7582
p.L6I	TCGA-FS-A1ZZ	SKCM	TCGA	KITLYED	LIG_APCC_ABBAyCdc20_2	0.6063
p.L6I	DO37412	SKCM	ICGC	KITLYED	LIG_APCC_ABBAyCdc20_2	0.6063
p.K3N	DO228276	BRCA	ICGC	KITLYED	LIG_APCC_ABBAyCdc20_2	0.6918
p.G2W	DO230347	COCA	ICGC	KITLYED	LIG_APCC_ABBAyCdc20_2	0.3056
p.R15H	DO234372	ESAD	ICGC	KITLYED	LIG_APCC_ABBAyCdc20_2	0.1667
p.I4M	SIDM01494	Glioblastoma	GDSC	KITLYED	LIG_APCC_ABBAyCdc20_2	0.6507
p.I4M	ACH-000445	Brain Cancer	CCLE	KITLYED	LIG_APCC_ABBAyCdc20_2	0.6507
p.R10W	ACH-002659	Colon/Colorectal Cancer	CCLE	KITLYED	LIG_APCC_ABBAyCdc20_2	0.3056
p.T5P	SU-DHL-10	haematopoietic_and_lymphoid_tissue	COSMIC	KITLYED	LIG_APCC_ABBAyCdc20_2	0.5919

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07320	Gamma-crystallin D	LIG_APCC_ABBAyCdc20_2	3:9	KITLYED	APC,CDC20,FZR1	0.731	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons