DegronMD

Uniprot ID: O95382

Source protein: Mitogen-activated protein kinase kinase kinase 6

Source gene: MAP3K6

Class: DEG_SCF_FBW7_2

Location: 800:805

E3 ligase: FBXW7

DEGRON score: 0.6798

ASA_SCORE: 66.2833

COIL: 0.8712

CONS_SCORE: 0.6282

DSS_SCORE: 0.2385

HELIX: 0.0613

FCONS_SCORE: 0.7406

RIG_SCORE: 0.8311

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F791C	TCGA-13-0920	OV	TCGA	ITPCTE	DEG_SCF_FBW7_2	0.0833
p.F791C	DO28099	OV	ICGC	ITPCTE	DEG_SCF_FBW7_2	0.0833
p.A798T	TCGA-A5-A1OF	UCEC	TCGA	ITPCTE	DEG_SCF_FBW7_2	0.2778
p.A798T	DO42568	UCEC	ICGC	ITPCTE	DEG_SCF_FBW7_2	0.2778
p.G792D	TCGA-DI-A1BU	UCEC	TCGA	ITPCTE	DEG_SCF_FBW7_2	0.1111
p.G792D	DO42023	UCEC	ICGC	ITPCTE	DEG_SCF_FBW7_2	0.1111
p.T806A	SIDM01287	Esophageal Carcinoma	GDSC	ITPCTE	DEG_SCF_FBW7_2	0.75
p.G809E	SIDM00516	Melanoma	GDSC	ITPCTE	DEG_SCF_FBW7_2	0.2222
p.G809E	MZ7-mel	skin	COSMIC	ITPCTE	DEG_SCF_FBW7_2	0.2222
p.G801E	MZ7-mel	skin	COSMIC	ITPCTE	DEG_SCF_FBW7_2	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95382	Mitogen-activated protein kinase kinase kinase 6	DEG_SCF_FBW7_2	800:805	ITPCTE	FBXW7	0.6798	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons