DegronMD

Uniprot ID: O00399

Source protein: Dynactin subunit 6

Source gene: DCTN6

Class: DEG_SCF_FBW7_2

Location: 70:75

E3 ligase: FBXW7

DEGRON score: 0.6889

ASA_SCORE: 75.7333

COIL: 0.842

CONS_SCORE: 0.1607

DSS_SCORE: 0.5575

HELIX: 0.0658

FCONS_SCORE: 0.3406

RIG_SCORE: 0.7322

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D76Y	TCGA-AP-A1DV	UCEC	TCGA	ITPDTE	DEG_SCF_FBW7_2	0.3056
p.D76Y	DO43186	UCEC	ICGC	ITPDTE	DEG_SCF_FBW7_2	0.3056
p.G85A	TCGA-BS-A0UF	UCEC	TCGA	ITPDTE	DEG_SCF_FBW7_2	0.0556
p.G85A	DO41488	UCEC	ICGC	ITPDTE	DEG_SCF_FBW7_2	0.0556
p.D76N	TCGA-E6-A1LX	UCEC	TCGA	ITPDTE	DEG_SCF_FBW7_2	0.3056
p.D76N	DO41020	UCEC	ICGC	ITPDTE	DEG_SCF_FBW7_2	0.3056
p.D73N	DO233276	GACA	ICGC	ITPDTE	DEG_SCF_FBW7_2	0.5821
p.A65V	SIDM00217	Colorectal Carcinoma	GDSC	ITPDTE	DEG_SCF_FBW7_2	0.1944
p.A65V	SNU-1040	large_intestine	COSMIC	ITPDTE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00399	Dynactin subunit 6	DEG_SCF_FBW7_2	70:75	ITPDTE	FBXW7	0.6889	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons