DegronMD

Uniprot ID: A5PLL1

Source protein: Ankyrin repeat domain-containing protein 34B

Source gene: ANKRD34B

Class: DEG_SCF_FBW7_2

Location: 271:276

E3 ligase: FBXW7

DEGRON score: 0.9944

ASA_SCORE: 70.4833

COIL: 0.4248

CONS_SCORE: 0.7219

DSS_SCORE: 0.4521

HELIX: 0.5608

FCONS_SCORE: 1.1659

RIG_SCORE: 0.7737

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E266K	TCGA-67-3771	LUAD	TCGA	ITPEEE	DEG_SCF_FBW7_2	0.1944
p.E266K	DO25797	LUAD	ICGC	ITPEEE	DEG_SCF_FBW7_2	0.1944
p.D270Y	TCGA-A8-A09T	BRCA	TCGA	ITPEEE	DEG_SCF_FBW7_2	0.3056
p.D270Y	DO2802	BRCA	ICGC	ITPEEE	DEG_SCF_FBW7_2	0.3056
p.T281I	TCGA-BF-A3DL	SKCM	TCGA	ITPEEE	DEG_SCF_FBW7_2	0.1944
p.T281I	DO51238	SKCM	ICGC	ITPEEE	DEG_SCF_FBW7_2	0.1944
p.L268F	TCGA-CD-A4MJ	STAD	TCGA	ITPEEE	DEG_SCF_FBW7_2	0.25
p.L268F	DO47811	STAD	ICGC	ITPEEE	DEG_SCF_FBW7_2	0.25
p.E275K	TCGA-ER-A194	SKCM	TCGA	ITPEEE	DEG_SCF_FBW7_2	0.591
p.E275K	DO222402	MELA	ICGC	ITPEEE	DEG_SCF_FBW7_2	0.591
p.E275K	DO47646	SKCM	ICGC	ITPEEE	DEG_SCF_FBW7_2	0.591
p.P273T	DO232445	PBCA	ICGC	ITPEEE	DEG_SCF_FBW7_2	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5PLL1	Ankyrin repeat domain-containing protein 34B	DEG_SCF_FBW7_2	271:276	ITPEEE	FBXW7	0.9944	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons