DegronMD - A5PLL1(ANKRD34B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E266K	TCGA-67-3771	LUAD	TCGA	ITPEEE	DEG_SCF_FBW7_2	271:276	Mutation rewiring degron network	0.1944
p.E266K	DO25797	LUAD	ICGC	ITPEEE	DEG_SCF_FBW7_2	271:276	Mutation rewiring degron network	0.1944
p.G387S	TCGA-92-7341	LUSC	TCGA	LTPPTS	DEG_SCF_FBW7_1	379:384	Mutation rewiring degron network	0.25
p.G387S	DO26677	LUSC	ICGC	LTPPTS	DEG_SCF_FBW7_1	379:384	Mutation rewiring degron network	0.25
p.D270Y	TCGA-A8-A09T	BRCA	TCGA	ITPEEE	DEG_SCF_FBW7_2	271:276	Mutation rewiring degron network	0.3056
p.D270Y	DO2802	BRCA	ICGC	ITPEEE	DEG_SCF_FBW7_2	271:276	Mutation rewiring degron network	0.3056
p.T281I	TCGA-BF-A3DL	SKCM	TCGA	ITPEEE	DEG_SCF_FBW7_2	271:276	Mutation rewiring degron network	0.1944
p.T281I	DO51238	SKCM	ICGC	ITPEEE	DEG_SCF_FBW7_2	271:276	Mutation rewiring degron network	0.1944
p.L390H	TCGA-BP-5189	KIRC	TCGA	LTPPTS	DEG_SCF_FBW7_1	379:384	Mutation rewiring degron network	0.1667
p.L390H	TCGA-CC-A9FW	LIHC	TCGA	LTPPTS	DEG_SCF_FBW7_1	379:384	Mutation rewiring degron network	0.1667
p.L390H	DO19480	KIRC	ICGC	LTPPTS	DEG_SCF_FBW7_1	379:384	Mutation rewiring degron network	0.1667
p.L390H	DO219557	LIHC	ICGC	LTPPTS	DEG_SCF_FBW7_1	379:384	Mutation rewiring degron network	0.1667
p.L268F	TCGA-CD-A4MJ	STAD	TCGA	ITPEEE	DEG_SCF_FBW7_2	271:276	Mutation rewiring degron network	0.25
p.L268F	DO47811	STAD	ICGC	ITPEEE	DEG_SCF_FBW7_2	271:276	Mutation rewiring degron network	0.25
p.S373F	TCGA-DD-AAEA	LIHC	TCGA	LTPPTS	DEG_SCF_FBW7_1	379:384	Mutation rewiring degron network	0.1667
p.S373F	DO52266	LIHC	ICGC	LTPPTS	DEG_SCF_FBW7_1	379:384	Mutation rewiring degron network	0.1667
p.E275K	TCGA-ER-A194	SKCM	TCGA	ITPEEE	DEG_SCF_FBW7_2	271:276	Mutation altering degron motif	0.591
p.E275K	DO222402	MELA	ICGC	ITPEEE	DEG_SCF_FBW7_2	271:276	Mutation altering degron motif	0.591
p.E275K	DO47646	SKCM	ICGC	ITPEEE	DEG_SCF_FBW7_2	271:276	Mutation altering degron motif	0.591
p.G392E	TCGA-FS-A1ZZ	SKCM	TCGA	LTPPTS	DEG_SCF_FBW7_1	379:384	Mutation rewiring degron network	0.1111
p.G392E	DO37412	SKCM	ICGC	LTPPTS	DEG_SCF_FBW7_1	379:384	Mutation rewiring degron network	0.1111
p.T380N	DO228985	LICA	ICGC	LTPPTS	DEG_SCF_FBW7_1	379:384	Mutation altering degron motif	0.7055
p.P273T	DO232445	PBCA	ICGC	ITPEEE	DEG_SCF_FBW7_2	271:276	Mutation altering degron motif	0.7031
p.P381H	SIDM01293	Colorectal Carcinoma	GDSC	LTPPTS	DEG_SCF_FBW7_1	379:384	Mutation altering degron motif	0.7694
p.P382L	SIDM01175	Other Sarcomas	GDSC	LTPPTS	DEG_SCF_FBW7_1	379:384	Mutation altering degron motif	0.6471
p.P382L	ACH-002309	Sarcoma	CCLE	LTPPTS	DEG_SCF_FBW7_1	379:384	Mutation altering degron motif	0.6471
p.P382L	SW684	soft tissue	COSMIC	LTPPTS	DEG_SCF_FBW7_1	379:384	Mutation altering degron motif	0.6471
p.P382Q	SIDM00094	Kidney Carcinoma	GDSC	LTPPTS	DEG_SCF_FBW7_1	379:384	Mutation altering degron motif	0.5924
p.P382Q	ACH-002199	Kidney Cancer	CCLE	LTPPTS	DEG_SCF_FBW7_1	379:384	Mutation altering degron motif	0.5924
p.P382Q	SN12C	kidney	COSMIC	LTPPTS	DEG_SCF_FBW7_1	379:384	Mutation altering degron motif	0.5924
p.A377T	SIDM00534	Colorectal Carcinoma	GDSC	LTPPTS	DEG_SCF_FBW7_1	379:384	Mutation rewiring degron network	0.2778
p.A377T	ACH-000986	Colon/Colorectal Cancer	CCLE	LTPPTS	DEG_SCF_FBW7_1	379:384	Mutation rewiring degron network	0.2778
p.A377T	HT-115	large intestine	COSMIC	LTPPTS	DEG_SCF_FBW7_1	379:384	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKRD34B

UniProt ID: A5PLL1

Entrez ID: 340120

Protein name: Ankyrin repeat domain-containing protein 34B

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ANKRD34B in