DegronMD

Uniprot ID: A5PLL1

Source protein: Ankyrin repeat domain-containing protein 34B

Source gene: ANKRD34B

Class: DEG_SCF_FBW7_1

Location: 379:384

E3 ligase: FBXW7

DEGRON score: 0.9945

ASA_SCORE: 67.8833

COIL: 0.95

CONS_SCORE: 0.4717

DSS_SCORE: 0.542

HELIX: 0.0177

FCONS_SCORE: 0.825

RIG_SCORE: 0.6191

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G387S	TCGA-92-7341	LUSC	TCGA	LTPPTS	DEG_SCF_FBW7_1	0.25
p.G387S	DO26677	LUSC	ICGC	LTPPTS	DEG_SCF_FBW7_1	0.25
p.L390H	TCGA-BP-5189	KIRC	TCGA	LTPPTS	DEG_SCF_FBW7_1	0.1667
p.L390H	TCGA-CC-A9FW	LIHC	TCGA	LTPPTS	DEG_SCF_FBW7_1	0.1667
p.L390H	DO19480	KIRC	ICGC	LTPPTS	DEG_SCF_FBW7_1	0.1667
p.L390H	DO219557	LIHC	ICGC	LTPPTS	DEG_SCF_FBW7_1	0.1667
p.S373F	TCGA-DD-AAEA	LIHC	TCGA	LTPPTS	DEG_SCF_FBW7_1	0.1667
p.S373F	DO52266	LIHC	ICGC	LTPPTS	DEG_SCF_FBW7_1	0.1667
p.G392E	TCGA-FS-A1ZZ	SKCM	TCGA	LTPPTS	DEG_SCF_FBW7_1	0.1111
p.G392E	DO37412	SKCM	ICGC	LTPPTS	DEG_SCF_FBW7_1	0.1111
p.T380N	DO228985	LICA	ICGC	LTPPTS	DEG_SCF_FBW7_1	0.7055
p.P381H	SIDM01293	Colorectal Carcinoma	GDSC	LTPPTS	DEG_SCF_FBW7_1	0.7694
p.P382L	SIDM01175	Other Sarcomas	GDSC	LTPPTS	DEG_SCF_FBW7_1	0.6471
p.P382L	ACH-002309	Sarcoma	CCLE	LTPPTS	DEG_SCF_FBW7_1	0.6471
p.P382L	SW684	soft_tissue	COSMIC	LTPPTS	DEG_SCF_FBW7_1	0.6471
p.P382Q	SIDM00094	Kidney Carcinoma	GDSC	LTPPTS	DEG_SCF_FBW7_1	0.5924
p.P382Q	ACH-002199	Kidney Cancer	CCLE	LTPPTS	DEG_SCF_FBW7_1	0.5924
p.P382Q	SN12C	kidney	COSMIC	LTPPTS	DEG_SCF_FBW7_1	0.5924
p.A377T	SIDM00534	Colorectal Carcinoma	GDSC	LTPPTS	DEG_SCF_FBW7_1	0.2778
p.A377T	ACH-000986	Colon/Colorectal Cancer	CCLE	LTPPTS	DEG_SCF_FBW7_1	0.2778
p.A377T	HT-115	large_intestine	COSMIC	LTPPTS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A5PLL1	Ankyrin repeat domain-containing protein 34B	DEG_SCF_FBW7_1	379:384	LTPPTS	FBXW7	0.9945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons