DegronMD

Uniprot ID: Q99798

Source protein: Aconitate hydratase, mitochondrial

Source gene: ACO2

Class: DEG_SCF_FBW7_2

Location: 416:421

E3 ligase: FBXW7

DEGRON score: 0.7027

ASA_SCORE: 32.3167

COIL: 0.6787

CONS_SCORE: 0.7605

DSS_SCORE: 0.3166

HELIX: 0.1832

FCONS_SCORE: 1.4099

RIG_SCORE: 0.7552

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S412F	TCGA-2W-A8YY	CESC	TCGA	ITPGSE	DEG_SCF_FBW7_2	0.2222
p.S412F	DO223732	CESC	ICGC	ITPGSE	DEG_SCF_FBW7_2	0.2222
p.A425T	TCGA-AX-A06F	UCEC	TCGA	ITPGSE	DEG_SCF_FBW7_2	0.2222
p.A425T	TCGA-AX-A1CE	UCEC	TCGA	ITPGSE	DEG_SCF_FBW7_2	0.2222
p.A425T	TCGA-EO-A22R	UCEC	TCGA	ITPGSE	DEG_SCF_FBW7_2	0.2222
p.A425T	DO42280	UCEC	ICGC	ITPGSE	DEG_SCF_FBW7_2	0.2222
p.A425T	DO41752	UCEC	ICGC	ITPGSE	DEG_SCF_FBW7_2	0.2222
p.A425T	DO42713	UCEC	ICGC	ITPGSE	DEG_SCF_FBW7_2	0.2222
p.R424H	TCGA-BR-8368	STAD	TCGA	ITPGSE	DEG_SCF_FBW7_2	0.25
p.R424H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ITPGSE	DEG_SCF_FBW7_2	0.25
p.R424H	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	ITPGSE	DEG_SCF_FBW7_2	0.25
p.E428D	TCGA-DX-A6YT	SARC	TCGA	ITPGSE	DEG_SCF_FBW7_2	0.1389
p.E428D	DO220007	SARC	ICGC	ITPGSE	DEG_SCF_FBW7_2	0.1389
p.G431R	TCGA-ER-A19P	SKCM	TCGA	ITPGSE	DEG_SCF_FBW7_2	0.0556
p.G431R	DO47623	SKCM	ICGC	ITPGSE	DEG_SCF_FBW7_2	0.0556
p.S421T	DO44051	BLCA	ICGC	ITPGSE	DEG_SCF_FBW7_2	0.7116
p.R420H	DO233674	GACA	ICGC	ITPGSE	DEG_SCF_FBW7_2	0.8244
p.A422S	DO15727	HNSC	ICGC	ITPGSE	DEG_SCF_FBW7_2	0.3056
p.S409G	DO45243	LIRI	ICGC	ITPGSE	DEG_SCF_FBW7_2	0.5833
p.C410S	DO46941	RECA	ICGC	ITPGSE	DEG_SCF_FBW7_2	0.1667
p.H406R	SIDM00901	Endometrial Carcinoma	GDSC	ITPGSE	DEG_SCF_FBW7_2	0.0556
p.H406R	AN3-CA	endometrium	COSMIC	ITPGSE	DEG_SCF_FBW7_2	0.0556
p.R420C	ACH-000950	Colon/Colorectal Cancer	CCLE	ITPGSE	DEG_SCF_FBW7_2	0.8301
p.R420C	LoVo	large_intestine	COSMIC	ITPGSE	DEG_SCF_FBW7_2	0.8301
p.T411I	ACH-000958	Colon/Colorectal Cancer	CCLE	ITPGSE	DEG_SCF_FBW7_2	0.6389
p.T411I	SW48	large_intestine	COSMIC	ITPGSE	DEG_SCF_FBW7_2	0.6389
p.I407T	ACH-000990	Endometrial/Uterine Cancer	CCLE	ITPGSE	DEG_SCF_FBW7_2	0.0833
p.S421L	ACH-001414	Bladder Cancer	CCLE	ITPGSE	DEG_SCF_FBW7_2	0.7667
p.H431R	AN3-CA	endometrium	COSMIC	ITPGSE	DEG_SCF_FBW7_2	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ITPGSE

Degron related mutations and impact score

Drug responses associated with ACO2 mutations

All proteins holding degron of ITPGSE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99798	Aconitate hydratase, mitochondrial	DEG_SCF_FBW7_2	416:421	ITPGSE	FBXW7	0.7027	More...