DegronMD - Q99798(ACO2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S412F	TCGA-2W-A8YY	CESC	TCGA	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation rewiring degron network	0.2222
p.S412F	DO223732	CESC	ICGC	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation rewiring degron network	0.2222
p.N746K	TCGA-78-8640	LUAD	TCGA	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	729:736	Mutation rewiring degron network	0.0556
p.N746K	DO45340	LUAD	ICGC	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	729:736	Mutation rewiring degron network	0.0556
p.A425T	TCGA-AX-A06F	UCEC	TCGA	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation rewiring degron network	0.2222
p.A425T	TCGA-AX-A1CE	UCEC	TCGA	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation rewiring degron network	0.2222
p.A425T	TCGA-EO-A22R	UCEC	TCGA	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation rewiring degron network	0.2222
p.A425T	DO42280	UCEC	ICGC	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation rewiring degron network	0.2222
p.A425T	DO41752	UCEC	ICGC	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation rewiring degron network	0.2222
p.A425T	DO42713	UCEC	ICGC	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation rewiring degron network	0.2222
p.R424H	TCGA-BR-8368	STAD	TCGA	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation rewiring degron network	0.25
p.R424H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation rewiring degron network	0.25
p.R424H	DND-41	haematopoietic and lymphoid tissue	COSMIC	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation rewiring degron network	0.25
p.Q727E	TCGA-D8-A27V	BRCA	TCGA	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	729:736	Mutation rewiring degron network	0.2778
p.Q727E	DO6048	BRCA	ICGC	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	729:736	Mutation rewiring degron network	0.2778
p.E428D	TCGA-DX-A6YT	SARC	TCGA	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation rewiring degron network	0.1389
p.E428D	DO220007	SARC	ICGC	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation rewiring degron network	0.1389
p.P745H	TCGA-EB-A1NK	SKCM	TCGA	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	729:736	Mutation rewiring degron network	0.0833
p.P745H	DO37695	SKCM	ICGC	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	729:736	Mutation rewiring degron network	0.0833
p.G431R	TCGA-ER-A19P	SKCM	TCGA	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation rewiring degron network	0.0556
p.G431R	DO47623	SKCM	ICGC	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation rewiring degron network	0.0556
p.S421T	DO44051	BLCA	ICGC	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation altering degron motif	0.7116
p.R420H	DO233674	GACA	ICGC	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation altering degron motif	0.8244
p.A422S	DO15727	HNSC	ICGC	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation rewiring degron network	0.3056
p.S409G	DO45243	LIRI	ICGC	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation blocking ubiquitination signal	0.5833
p.C410S	DO46941	RECA	ICGC	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation rewiring degron network	0.1667
p.C740Y	SIDM00783	Colorectal Carcinoma	GDSC	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	729:736	Mutation rewiring degron network	0.2222
p.C740Y	HCT-116	large intestine	COSMIC	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	729:736	Mutation rewiring degron network	0.2222
p.H406R	SIDM00901	Endometrial Carcinoma	GDSC	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation rewiring degron network	0.0556
p.H406R	AN3-CA	endometrium	COSMIC	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation rewiring degron network	0.0556
p.T722A	ACH-000132	Ovarian Cancer	CCLE	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	729:736	Mutation rewiring degron network	0.1389
p.T722A	JHOS-2	ovary	COSMIC	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	729:736	Mutation rewiring degron network	0.1389
p.T722N	ACH-000691	Breast Cancer	CCLE	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	729:736	Mutation rewiring degron network	0.1389
p.T722N	HCC2157	breast	COSMIC	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	729:736	Mutation rewiring degron network	0.1389
p.L732V	ACH-000861	Lung Cancer	CCLE	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	729:736	Mutation altering degron motif	0.6765
p.L732V	HOP-62	lung	COSMIC	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	729:736	Mutation altering degron motif	0.6765
p.R420C	ACH-000950	Colon/Colorectal Cancer	CCLE	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation altering degron motif	0.8301
p.R420C	LoVo	large intestine	COSMIC	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation altering degron motif	0.8301
p.T411I	ACH-000958	Colon/Colorectal Cancer	CCLE	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation blocking ubiquitination signal	0.6389
p.T411I	SW48	large intestine	COSMIC	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation blocking ubiquitination signal	0.6389
p.P731S	ACH-000958	Colon/Colorectal Cancer	CCLE	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	729:736	Mutation altering degron motif	0.6752
p.P731S	SW48	large intestine	COSMIC	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	729:736	Mutation altering degron motif	0.6752
p.I407T	ACH-000990	Endometrial/Uterine Cancer	CCLE	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation rewiring degron network	0.0833
p.S421L	ACH-001414	Bladder Cancer	CCLE	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation altering degron motif	0.7667
p.H431R	AN3-CA	endometrium	COSMIC	ITPGSE	DEG_SCF_FBW7_2	416:421	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ACO2

UniProt ID: Q99798

Entrez ID: 50

Protein name: Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ACO2 in