DegronMD

Uniprot ID: Q99798

Source protein: Aconitate hydratase, mitochondrial

Source gene: ACO2

Class: DEG_SCF_SKP2-CKS1_1

Location: 729:736

E3 ligase: SKP2,CSK1

DEGRON score: 0.8946

ASA_SCORE: 72.9

COIL: 0.7026

CONS_SCORE: 0.3766

DSS_SCORE: 0.2456

HELIX: 0.1398

FCONS_SCORE: 1.1609

RIG_SCORE: 0.7619

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N746K	TCGA-78-8640	LUAD	TCGA	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	0.0556
p.N746K	DO45340	LUAD	ICGC	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	0.0556
p.Q727E	TCGA-D8-A27V	BRCA	TCGA	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	0.2778
p.Q727E	DO6048	BRCA	ICGC	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	0.2778
p.P745H	TCGA-EB-A1NK	SKCM	TCGA	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	0.0833
p.P745H	DO37695	SKCM	ICGC	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	0.0833
p.C740Y	SIDM00783	Colorectal Carcinoma	GDSC	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	0.2222
p.C740Y	HCT-116	large_intestine	COSMIC	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	0.2222
p.T722A	ACH-000132	Ovarian Cancer	CCLE	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	0.1389
p.T722A	JHOS-2	ovary	COSMIC	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	0.1389
p.T722N	ACH-000691	Breast Cancer	CCLE	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	0.1389
p.T722N	HCC2157	breast	COSMIC	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	0.1389
p.L732V	ACH-000861	Lung Cancer	CCLE	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	0.6765
p.L732V	HOP-62	lung	COSMIC	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	0.6765
p.P731S	ACH-000958	Colon/Colorectal Cancer	CCLE	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	0.6752
p.P731S	SW48	large_intestine	COSMIC	LKDFTPGK	DEG_SCF_SKP2-CKS1_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99798	Aconitate hydratase, mitochondrial	DEG_SCF_SKP2-CKS1_1	729:736	LKDFTPGK	SKP2,CSK1	0.8946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons