DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ITPLHT
Uniprot ID:
Q96SY0
Source protein:
Integrator complex subunit 14
Source gene:
INTS14
Class:
DEG_SCF_FBW7_1
Location:
503:508
E3 ligase:
FBXW7
DEGRON score:
0.8319
ASA_SCORE:
50
COIL:
0.6123
CONS_SCORE:
0.5895
DSS_SCORE:
0.4131
HELIX:
0.0378
FCONS_SCORE:
1.489
RIG_SCORE:
0.7528
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with INTS14 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ITPLHT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96SY0
Integrator complex subunit 14
DEG_SCF_FBW7_1
503:508
ITPLHT
FBXW7
0.8319
More...