DegronMD

Uniprot ID: P46109

Source protein: Crk-like protein

Source gene: CRKL

Class: DEG_SCF_FBW7_1

Location: 227:232

E3 ligase: FBXW7

DEGRON score: 0.999

ASA_SCORE: 73.7667

COIL: 0.8638

CONS_SCORE: 0.3657

DSS_SCORE: 0.4997

HELIX: 0.025

FCONS_SCORE: 0.7786

RIG_SCORE: 0.697

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A225S	TCGA-86-8673	LUAD	TCGA	ITPLPS	DEG_SCF_FBW7_1	0.2778
p.A225S	DO26260	LUAD	ICGC	ITPLPS	DEG_SCF_FBW7_1	0.2778
p.G224V	TCGA-A5-A0VQ	UCEC	TCGA	ITPLPS	DEG_SCF_FBW7_1	0.25
p.G224V	TCGA-EE-A2MM	SKCM	TCGA	ITPLPS	DEG_SCF_FBW7_1	0.25
p.G224V	DO37770	SKCM	ICGC	ITPLPS	DEG_SCF_FBW7_1	0.25
p.G224V	DO42113	UCEC	ICGC	ITPLPS	DEG_SCF_FBW7_1	0.25
p.P229H	TCGA-AX-A1C4	UCEC	TCGA	ITPLPS	DEG_SCF_FBW7_1	0.7694
p.P229H	DO42480	UCEC	ICGC	ITPLPS	DEG_SCF_FBW7_1	0.7694
p.Q234E	DO234255	ESAD	ICGC	ITPLPS	DEG_SCF_FBW7_1	0.2778
p.P231Q	DO229027	LICA	ICGC	ITPLPS	DEG_SCF_FBW7_1	0.5924
p.P217R	DO218856	SKCA	ICGC	ITPLPS	DEG_SCF_FBW7_1	0.0556
p.T228N	SIDM00845	Burkitt's Lymphoma	GDSC	ITPLPS	DEG_SCF_FBW7_1	0.8166
p.G236A	SIDM00044	Head and Neck Carcinoma	GDSC	ITPLPS	DEG_SCF_FBW7_1	0.2222
p.G236A	ACH-002295	Head and Neck Cancer	CCLE	ITPLPS	DEG_SCF_FBW7_1	0.2222
p.G236A	PCI-30	upper_aerodigestive_tract	COSMIC	ITPLPS	DEG_SCF_FBW7_1	0.2222
p.A225V	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ITPLPS	DEG_SCF_FBW7_1	0.2778
p.A225V	ACH-001737	Leukemia	CCLE	ITPLPS	DEG_SCF_FBW7_1	0.2778
p.A225V	ACH-002222	Leukemia	CCLE	ITPLPS	DEG_SCF_FBW7_1	0.2778
p.A225V	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	ITPLPS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46109	Crk-like protein	DEG_SCF_FBW7_1	227:232	ITPLPS	FBXW7	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons