DegronMD - P46109(CRKL)

GO - Biological processes (BP): acetylcholine receptor signaling pathway [GO:0095500]; activation of GTPase activity [GO:0090630]; anterior/posterior pattern specification [GO:0009952]; B cell apoptotic process [GO:0001783]; blood vessel development [GO:0001568]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cellular response to interleukin-7 [GO:0098761]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to xenobiotic stimulus [GO:0071466]; cerebellar neuron development [GO:0098749]; cerebral cortex development [GO:0021987]; cranial skeletal system development [GO:1904888]; dendrite development [GO:0016358]; endothelin receptor signaling pathway [GO:0086100]; establishment of cell polarity [GO:0030010]; fibroblast growth factor receptor signaling pathway [GO:0008543]; helper T cell diapedesis [GO:0035685]; hippocampus development [GO:0021766]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; lipid metabolic process [GO:0006629]; male gonad development [GO:0008584]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; parathyroid gland development [GO:0060017]; pharynx development [GO:0060465]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glial cell migration [GO:1903977]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; Ras protein signal transduction [GO:0007265]; reelin-mediated signaling pathway [GO:0038026]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cell growth [GO:0001558]; regulation of dendrite development [GO:0050773]; regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904393]; regulation of T cell migration [GO:2000404]; retinoic acid receptor signaling pathway [GO:0048384]; signal transduction [GO:0007165]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]; synapse assembly [GO:0007416]; T cell receptor signaling pathway [GO:0050852]; thymus development [GO:0048538]; urogenital system development [GO:0001655] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q211E	TCGA-63-5131	LUSC	TCGA	PQTTT	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.5633
p.Q211E	DO26898	LUSC	ICGC	PQTTT	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.5633
p.A225S	TCGA-86-8673	LUAD	TCGA	ITPLPS	DEG_SCF_FBW7_1	227:232	Mutation rewiring degron network	0.2778
p.A225S	DO26260	LUAD	ICGC	ITPLPS	DEG_SCF_FBW7_1	227:232	Mutation rewiring degron network	0.2778
p.G224V	TCGA-A5-A0VQ	UCEC	TCGA	ITPLPS	DEG_SCF_FBW7_1	227:232	Mutation rewiring degron network	0.25
p.G224V	TCGA-A5-A0VQ	UCEC	TCGA	PQTTT	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.0556
p.G224V	TCGA-EE-A2MM	SKCM	TCGA	ITPLPS	DEG_SCF_FBW7_1	227:232	Mutation rewiring degron network	0.25
p.G224V	TCGA-EE-A2MM	SKCM	TCGA	PQTTT	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.0556
p.G224V	DO37770	SKCM	ICGC	ITPLPS	DEG_SCF_FBW7_1	227:232	Mutation rewiring degron network	0.25
p.G224V	DO37770	SKCM	ICGC	PQTTT	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.0556
p.G224V	DO42113	UCEC	ICGC	ITPLPS	DEG_SCF_FBW7_1	227:232	Mutation rewiring degron network	0.25
p.G224V	DO42113	UCEC	ICGC	PQTTT	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.0556
p.H205R	TCGA-AA-3492	COAD	TCGA	PQTTT	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.1944
p.H205R	DO8224	COAD	ICGC	PQTTT	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.1944
p.P229H	TCGA-AX-A1C4	UCEC	TCGA	ITPLPS	DEG_SCF_FBW7_1	227:232	Mutation altering degron motif	0.7694
p.P229H	DO42480	UCEC	ICGC	ITPLPS	DEG_SCF_FBW7_1	227:232	Mutation altering degron motif	0.7694
p.Q211H	TCGA-AX-A2HC	UCEC	TCGA	PQTTT	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.647
p.Q211H	DO41572	UCEC	ICGC	PQTTT	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.647
p.A206T	TCGA-DU-6392	LGG	TCGA	PQTTT	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.2222
p.A206T	DO22237	LGG	ICGC	PQTTT	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.2222
p.Q234E	DO234255	ESAD	ICGC	ITPLPS	DEG_SCF_FBW7_1	227:232	Mutation rewiring degron network	0.2778
p.P231Q	DO229027	LICA	ICGC	ITPLPS	DEG_SCF_FBW7_1	227:232	Mutation altering degron motif	0.5924
p.P217R	DO218856	SKCA	ICGC	ITPLPS	DEG_SCF_FBW7_1	227:232	Mutation rewiring degron network	0.0556
p.P217R	DO218856	SKCA	ICGC	PQTTT	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.25
p.T228N	SIDM00845	Burkitt's Lymphoma	GDSC	ITPLPS	DEG_SCF_FBW7_1	227:232	Mutation altering degron motif	0.8166
p.G236A	SIDM00044	Head and Neck Carcinoma	GDSC	ITPLPS	DEG_SCF_FBW7_1	227:232	Mutation rewiring degron network	0.2222
p.G236A	ACH-002295	Head and Neck Cancer	CCLE	ITPLPS	DEG_SCF_FBW7_1	227:232	Mutation rewiring degron network	0.2222
p.G236A	PCI-30	upper aerodigestive tract	COSMIC	ITPLPS	DEG_SCF_FBW7_1	227:232	Mutation rewiring degron network	0.2222
p.A225V	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ITPLPS	DEG_SCF_FBW7_1	227:232	Mutation rewiring degron network	0.2778
p.A225V	ACH-001737	Leukemia	CCLE	ITPLPS	DEG_SCF_FBW7_1	227:232	Mutation rewiring degron network	0.2778
p.A225V	ACH-002222	Leukemia	CCLE	ITPLPS	DEG_SCF_FBW7_1	227:232	Mutation rewiring degron network	0.2778
p.A225V	CTV-1	haematopoietic and lymphoid tissue	COSMIC	ITPLPS	DEG_SCF_FBW7_1	227:232	Mutation rewiring degron network	0.2778

Kaplan plot for CRKL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CRKL

UniProt ID: P46109

Entrez ID: 1399

Protein name: Crk-like protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CRKL in