DegronMD

Uniprot ID: P46109

Source protein: Crk-like protein

Source gene: CRKL

Class: DEG_SPOP_SBC_1

Location: 210:214

E3 ligase: SPOP

DEGRON score: 0.9506

ASA_SCORE: 88.3

COIL: 0.8846

CONS_SCORE: 0.4337

DSS_SCORE: 0.6388

HELIX: 0.042

FCONS_SCORE: 1.0368

RIG_SCORE: 0.6552

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q211E	TCGA-63-5131	LUSC	TCGA	PQTTT	DEG_SPOP_SBC_1	0.5633
p.Q211E	DO26898	LUSC	ICGC	PQTTT	DEG_SPOP_SBC_1	0.5633
p.G224V	TCGA-A5-A0VQ	UCEC	TCGA	PQTTT	DEG_SPOP_SBC_1	0.0556
p.G224V	TCGA-EE-A2MM	SKCM	TCGA	PQTTT	DEG_SPOP_SBC_1	0.0556
p.G224V	DO37770	SKCM	ICGC	PQTTT	DEG_SPOP_SBC_1	0.0556
p.G224V	DO42113	UCEC	ICGC	PQTTT	DEG_SPOP_SBC_1	0.0556
p.H205R	TCGA-AA-3492	COAD	TCGA	PQTTT	DEG_SPOP_SBC_1	0.1944
p.H205R	DO8224	COAD	ICGC	PQTTT	DEG_SPOP_SBC_1	0.1944
p.Q211H	TCGA-AX-A2HC	UCEC	TCGA	PQTTT	DEG_SPOP_SBC_1	0.647
p.Q211H	DO41572	UCEC	ICGC	PQTTT	DEG_SPOP_SBC_1	0.647
p.A206T	TCGA-DU-6392	LGG	TCGA	PQTTT	DEG_SPOP_SBC_1	0.2222
p.A206T	DO22237	LGG	ICGC	PQTTT	DEG_SPOP_SBC_1	0.2222
p.P217R	DO218856	SKCA	ICGC	PQTTT	DEG_SPOP_SBC_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons