DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PQTTT
Uniprot ID:
P98088
Source protein:
Mucin-5AC
Source gene:
MUC5AC
Class:
DEG_SPOP_SBC_1
Location:
3716:3720
E3 ligase:
SPOP
DEGRON score:
0.9256
ASA_SCORE:
102.58
COIL:
0.9384
CONS_SCORE:
0.3577
DSS_SCORE:
0.6288
HELIX:
0.0196
FCONS_SCORE:
1.1861
RIG_SCORE:
0.6288
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T3720I
SIDM01120
Other Solid Cancers
GDSC
PQTTT
DEG_SPOP_SBC_1
0.7078
Drug responses associated with MUC5AC mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PQTTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P46109
Crk-like protein
DEG_SPOP_SBC_1
210:214
PQTTT
SPOP
0.9506
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
3716:3720
PQTTT
SPOP
0.9256
More...