DegronMD

Uniprot ID: Q96QE5

Source protein: Transcription elongation factor, mitochondrial

Source gene: TEFM

Class: DEG_SCF_FBW7_1

Location: 43:48

E3 ligase: FBXW7

DEGRON score: 0.7394

ASA_SCORE: 85.9667

COIL: 0.8078

CONS_SCORE: 0.2541

DSS_SCORE: 0.381

HELIX: 0.0298

FCONS_SCORE: 0.8575

RIG_SCORE: 0.79

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R34W	TCGA-BS-A0UV	UCEC	TCGA	ITPNVT	DEG_SCF_FBW7_1	0.0833
p.R34W	DO42793	UCEC	ICGC	ITPNVT	DEG_SCF_FBW7_1	0.0833
p.R34W	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	ITPNVT	DEG_SCF_FBW7_1	0.0833
p.D51A	TCGA-D7-A4Z0	STAD	TCGA	ITPNVT	DEG_SCF_FBW7_1	0.25
p.D51A	DO47765	STAD	ICGC	ITPNVT	DEG_SCF_FBW7_1	0.25
p.P45H	SIDM00217	Colorectal Carcinoma	GDSC	ITPNVT	DEG_SCF_FBW7_1	0.7694
p.P45H	ACH-000999	Colon/Colorectal Cancer	CCLE	ITPNVT	DEG_SCF_FBW7_1	0.7694
p.P45H	SNU-1040	large_intestine	COSMIC	ITPNVT	DEG_SCF_FBW7_1	0.7694
p.C50F	SIDM01611	Endometrial Carcinoma	GDSC	ITPNVT	DEG_SCF_FBW7_1	0.2778
p.C50F	ACH-000996	Endometrial/Uterine Cancer	CCLE	ITPNVT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96QE5	Transcription elongation factor, mitochondrial	DEG_SCF_FBW7_1	43:48	ITPNVT	FBXW7	0.7394	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons