DegronMD

Uniprot ID: Q76FK4

Source protein: Nucleolar protein 8

Source gene: NOL8

Class: DEG_SCF_FBW7_1

Location: 262:267

E3 ligase: FBXW7

DEGRON score: 0.997

ASA_SCORE: 103.3167

COIL: 0.9577

CONS_SCORE: 0.2997

DSS_SCORE: 0.6382

HELIX: 0.0205

FCONS_SCORE: 1.1289

RIG_SCORE: 0.6126

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P271H	TCGA-66-2744	LUSC	TCGA	ITPSKS	DEG_SCF_FBW7_1	0.2222
p.S265Y	TCGA-A5-A0G2	UCEC	TCGA	ITPSKS	DEG_SCF_FBW7_1	0.712
p.A253V	TCGA-DI-A1BU	UCEC	TCGA	ITPSKS	DEG_SCF_FBW7_1	0.0833
p.Q276K	TCGA-EE-A3AG	SKCM	TCGA	ITPSKS	DEG_SCF_FBW7_1	0.0833
p.S268F	TCGA-W3-AA1Q	SKCM	TCGA	ITPSKS	DEG_SCF_FBW7_1	0.75
p.E262K	DO219083	BLCA	ICGC	ITPSKS	DEG_SCF_FBW7_1	0.7022
p.E262K	DO14393	HNSC	ICGC	ITPSKS	DEG_SCF_FBW7_1	0.7022
p.P256H	DO229028	LICA	ICGC	ITPSKS	DEG_SCF_FBW7_1	0.6111
p.E267K	DO220883	MELA	ICGC	ITPSKS	DEG_SCF_FBW7_1	0.7022
p.R270M	DO47278	SKCM	ICGC	ITPSKS	DEG_SCF_FBW7_1	0.25
p.D271G	DO43434	UCEC	ICGC	ITPSKS	DEG_SCF_FBW7_1	0.2222
p.P269T	SIDM00735	Small Cell Lung Carcinoma	GDSC	ITPSKS	DEG_SCF_FBW7_1	0.2778
p.P269T	NCI-H2029	lung	COSMIC	ITPSKS	DEG_SCF_FBW7_1	0.2778
p.R257I	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	ITPSKS	DEG_SCF_FBW7_1	0.1944
p.R257I	ACH-000841	Lung Cancer	CCLE	ITPSKS	DEG_SCF_FBW7_1	0.1944
p.R257I	NCI-H2087	lung	COSMIC	ITPSKS	DEG_SCF_FBW7_1	0.1944
p.S261Y	ACH-002287	Colon/Colorectal Cancer	CCLE	ITPSKS	DEG_SCF_FBW7_1	0.3056
p.S261Y	NCI-H630	large_intestine	COSMIC	ITPSKS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q76FK4	Nucleolar protein 8	DEG_SCF_FBW7_1	262:267	ITPSKS	FBXW7	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons