DegronMD - Q76FK4(NOL8)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K940N	TCGA-64-1679	LUAD	TCGA	KDIIHYD	LIG_APCC_ABBAyCdc20_2	942:948	Mutation rewiring degron network	0.2778
p.P271H	TCGA-66-2744	LUSC	TCGA	ITPSKS	DEG_SCF_FBW7_1	262:267	Mutation rewiring degron network	0.2222
p.S265Y	TCGA-A5-A0G2	UCEC	TCGA	ITPSKS	DEG_SCF_FBW7_1	262:267	Mutation altering degron motif	0.712
p.F941C	TCGA-D1-A16X	UCEC	TCGA	KDIIHYD	LIG_APCC_ABBAyCdc20_2	942:948	Mutation rewiring degron network	0.3056
p.F941C	TCGA-EO-A22X	UCEC	TCGA	KDIIHYD	LIG_APCC_ABBAyCdc20_2	942:948	Mutation rewiring degron network	0.3056
p.A253V	TCGA-DI-A1BU	UCEC	TCGA	ITPSKS	DEG_SCF_FBW7_1	262:267	Mutation rewiring degron network	0.0833
p.E958K	TCGA-DK-A6AW	BLCA	TCGA	KDIIHYD	LIG_APCC_ABBAyCdc20_2	942:948	Mutation rewiring degron network	0.0556
p.Q276K	TCGA-EE-A3AG	SKCM	TCGA	ITPSKS	DEG_SCF_FBW7_1	262:267	Mutation rewiring degron network	0.0833
p.K940T	TCGA-IB-7651	PAAD	TCGA	KDIIHYD	LIG_APCC_ABBAyCdc20_2	942:948	Mutation rewiring degron network	0.2778
p.S268F	TCGA-W3-AA1Q	SKCM	TCGA	ITPSKS	DEG_SCF_FBW7_1	262:267	Mutation blocking phosphorylation signal	0.75
p.E262K	DO219083	BLCA	ICGC	ITPSKS	DEG_SCF_FBW7_1	262:267	Mutation altering degron motif	0.7022
p.E262K	DO14393	HNSC	ICGC	ITPSKS	DEG_SCF_FBW7_1	262:267	Mutation altering degron motif	0.7022
p.G953S	DO234285	ESAD	ICGC	KDIIHYD	LIG_APCC_ABBAyCdc20_2	942:948	Mutation rewiring degron network	0.1944
p.T946K	DO229018	LICA	ICGC	KDIIHYD	LIG_APCC_ABBAyCdc20_2	942:948	Mutation altering degron motif	0.7306
p.P256H	DO229028	LICA	ICGC	ITPSKS	DEG_SCF_FBW7_1	262:267	Mutation blocking ubiquitination signal	0.6111
p.E267K	DO220883	MELA	ICGC	ITPSKS	DEG_SCF_FBW7_1	262:267	Mutation altering degron motif	0.7022
p.R270M	DO47278	SKCM	ICGC	ITPSKS	DEG_SCF_FBW7_1	262:267	Mutation rewiring degron network	0.25
p.K942N	DO37778	SKCM	ICGC	KDIIHYD	LIG_APCC_ABBAyCdc20_2	942:948	Mutation altering degron motif	0.6918
p.I932K	DO38404	STAD	ICGC	KDIIHYD	LIG_APCC_ABBAyCdc20_2	942:948	Mutation rewiring degron network	0.0556
p.D271G	DO43434	UCEC	ICGC	ITPSKS	DEG_SCF_FBW7_1	262:267	Mutation rewiring degron network	0.2222
p.P269T	SIDM00735	Small Cell Lung Carcinoma	GDSC	ITPSKS	DEG_SCF_FBW7_1	262:267	Mutation rewiring degron network	0.2778
p.P269T	NCI-H2029	lung	COSMIC	ITPSKS	DEG_SCF_FBW7_1	262:267	Mutation rewiring degron network	0.2778
p.R257I	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	ITPSKS	DEG_SCF_FBW7_1	262:267	Mutation rewiring degron network	0.1944
p.R257I	ACH-000841	Lung Cancer	CCLE	ITPSKS	DEG_SCF_FBW7_1	262:267	Mutation rewiring degron network	0.1944
p.R257I	NCI-H2087	lung	COSMIC	ITPSKS	DEG_SCF_FBW7_1	262:267	Mutation rewiring degron network	0.1944
p.A937S	SIDM00214	Colorectal Carcinoma	GDSC	KDIIHYD	LIG_APCC_ABBAyCdc20_2	942:948	Mutation rewiring degron network	0.1944
p.A937S	SNU-407	large intestine	COSMIC	KDIIHYD	LIG_APCC_ABBAyCdc20_2	942:948	Mutation rewiring degron network	0.1944
p.R938T	ACH-000892	Lung Cancer	CCLE	KDIIHYD	LIG_APCC_ABBAyCdc20_2	942:948	Mutation rewiring degron network	0.2222
p.R938T	NCI-H1563	lung	COSMIC	KDIIHYD	LIG_APCC_ABBAyCdc20_2	942:948	Mutation rewiring degron network	0.2222
p.S261Y	ACH-002287	Colon/Colorectal Cancer	CCLE	ITPSKS	DEG_SCF_FBW7_1	262:267	Mutation rewiring degron network	0.3056
p.S261Y	NCI-H630	large intestine	COSMIC	ITPSKS	DEG_SCF_FBW7_1	262:267	Mutation rewiring degron network	0.3056

Kaplan plot for NOL8 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NOL8

UniProt ID: Q76FK4

Entrez ID: 55035

Protein name: Nucleolar protein 8 (Nucleolar protein Nop132)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for NOL8 in