DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
KDIIHYD
Uniprot ID:
Q76FK4
Source protein:
Nucleolar protein 8
Source gene:
NOL8
Class:
LIG_APCC_ABBAyCdc20_2
Location:
942:948
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8686
ASA_SCORE:
84.6143
COIL:
0.7049
CONS_SCORE:
0.5312
DSS_SCORE:
0.4524
HELIX:
0.1061
FCONS_SCORE:
1.129
RIG_SCORE:
0.7805
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K940N
TCGA-64-1679
LUAD
TCGA
KDIIHYD
LIG_APCC_ABBAyCdc20_2
0.2778
p.F941C
TCGA-D1-A16X
UCEC
TCGA
KDIIHYD
LIG_APCC_ABBAyCdc20_2
0.3056
p.F941C
TCGA-EO-A22X
UCEC
TCGA
KDIIHYD
LIG_APCC_ABBAyCdc20_2
0.3056
p.E958K
TCGA-DK-A6AW
BLCA
TCGA
KDIIHYD
LIG_APCC_ABBAyCdc20_2
0.0556
p.K940T
TCGA-IB-7651
PAAD
TCGA
KDIIHYD
LIG_APCC_ABBAyCdc20_2
0.2778
p.G953S
DO234285
ESAD
ICGC
KDIIHYD
LIG_APCC_ABBAyCdc20_2
0.1944
p.T946K
DO229018
LICA
ICGC
KDIIHYD
LIG_APCC_ABBAyCdc20_2
0.7306
p.K942N
DO37778
SKCM
ICGC
KDIIHYD
LIG_APCC_ABBAyCdc20_2
0.6918
p.I932K
DO38404
STAD
ICGC
KDIIHYD
LIG_APCC_ABBAyCdc20_2
0.0556
p.A937S
SIDM00214
Colorectal Carcinoma
GDSC
KDIIHYD
LIG_APCC_ABBAyCdc20_2
0.1944
p.A937S
SNU-407
large_intestine
COSMIC
KDIIHYD
LIG_APCC_ABBAyCdc20_2
0.1944
p.R938T
ACH-000892
Lung Cancer
CCLE
KDIIHYD
LIG_APCC_ABBAyCdc20_2
0.2222
p.R938T
NCI-H1563
lung
COSMIC
KDIIHYD
LIG_APCC_ABBAyCdc20_2
0.2222
Drug responses associated with NOL8 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KDIIHYD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q76FK4
Nucleolar protein 8
LIG_APCC_ABBAyCdc20_2
942:948
KDIIHYD
APC,CDC20,FZR1
0.8686
More...