DegronMD

Uniprot ID: Q76FK4

Source protein: Nucleolar protein 8

Source gene: NOL8

Class: LIG_APCC_ABBAyCdc20_2

Location: 942:948

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8686

ASA_SCORE: 84.6143

COIL: 0.7049

CONS_SCORE: 0.5312

DSS_SCORE: 0.4524

HELIX: 0.1061

FCONS_SCORE: 1.129

RIG_SCORE: 0.7805

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T946K	DO229018	LICA	ICGC	KDIIHYD	LIG_APCC_ABBAyCdc20_2	0.7306
p.K942N	DO37778	SKCM	ICGC	KDIIHYD	LIG_APCC_ABBAyCdc20_2	0.6918
p.F941C	TCGA-D1-A16X	UCEC	TCGA	KDIIHYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.F941C	TCGA-EO-A22X	UCEC	TCGA	KDIIHYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.K940N	TCGA-64-1679	LUAD	TCGA	KDIIHYD	LIG_APCC_ABBAyCdc20_2	0.2778
p.K940T	TCGA-IB-7651	PAAD	TCGA	KDIIHYD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R938T	ACH-000892	Lung Cancer	CCLE	KDIIHYD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R938T	NCI-H1563	lung	COSMIC	KDIIHYD	LIG_APCC_ABBAyCdc20_2	0.2222
p.G953S	DO234285	ESAD	ICGC	KDIIHYD	LIG_APCC_ABBAyCdc20_2	0.1944
p.A937S	SIDM00214	Colorectal Carcinoma	GDSC	KDIIHYD	LIG_APCC_ABBAyCdc20_2	0.1944
p.A937S	SNU-407	large_intestine	COSMIC	KDIIHYD	LIG_APCC_ABBAyCdc20_2	0.1944
p.E958K	TCGA-DK-A6AW	BLCA	TCGA	KDIIHYD	LIG_APCC_ABBAyCdc20_2	0.0556
p.I932K	DO38404	STAD	ICGC	KDIIHYD	LIG_APCC_ABBAyCdc20_2	0.0556

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q76FK4	Nucleolar protein 8	LIG_APCC_ABBAyCdc20_2	942:948	KDIIHYD	APC,CDC20,FZR1	0.8686	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons