DegronMD

Uniprot ID: O43610

Source protein: Protein sprouty homolog 3

Source gene: SPRY3

Class: DEG_SCF_FBW7_1

Location: 103:108

E3 ligase: FBXW7

DEGRON score: 0.9616

ASA_SCORE: 81.6167

COIL: 0.9073

CONS_SCORE: 0.3969

DSS_SCORE: 0.6086

HELIX: 0.0265

FCONS_SCORE: 1.0089

RIG_SCORE: 0.6249

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G109C	TCGA-37-4135	LUSC	TCGA	ITPSPS	DEG_SCF_FBW7_1	0.3056
p.G109C	DO26806	LUSC	ICGC	ITPSPS	DEG_SCF_FBW7_1	0.3056
p.Q97E	TCGA-4J-AA1J	CESC	TCGA	ITPSPS	DEG_SCF_FBW7_1	0.1667
p.Q97E	DO219718	CESC	ICGC	ITPSPS	DEG_SCF_FBW7_1	0.1667
p.R98M	TCGA-56-1622	LUSC	TCGA	ITPSPS	DEG_SCF_FBW7_1	0.1944
p.R98M	DO26461	LUSC	ICGC	ITPSPS	DEG_SCF_FBW7_1	0.1944
p.R114L	TCGA-70-6722	LUSC	TCGA	ITPSPS	DEG_SCF_FBW7_1	0.1667
p.R114L	DO27755	LUSC	ICGC	ITPSPS	DEG_SCF_FBW7_1	0.1667
p.R114Q	TCGA-AG-3892	READ	TCGA	ITPSPS	DEG_SCF_FBW7_1	0.1667
p.R114Q	DO36394	READ	ICGC	ITPSPS	DEG_SCF_FBW7_1	0.1667
p.R114Q	SIDM02018	Colorectal Carcinoma	GDSC	ITPSPS	DEG_SCF_FBW7_1	0.1667
p.R114Q	SIDM00451	T-Lymphoblastic Leukemia	GDSC	ITPSPS	DEG_SCF_FBW7_1	0.1667
p.S108L	TCGA-BF-A1Q0	SKCM	TCGA	ITPSPS	DEG_SCF_FBW7_1	0.7667
p.S108L	TCGA-FW-A5DY	SKCM	TCGA	ITPSPS	DEG_SCF_FBW7_1	0.7667
p.S108L	DO47257	SKCM	ICGC	ITPSPS	DEG_SCF_FBW7_1	0.7667
p.S108L	DO47374	SKCM	ICGC	ITPSPS	DEG_SCF_FBW7_1	0.7667
p.G109V	TCGA-CM-5864	COAD	TCGA	ITPSPS	DEG_SCF_FBW7_1	0.3056
p.G109V	DO8690	COAD	ICGC	ITPSPS	DEG_SCF_FBW7_1	0.3056
p.A94T	TCGA-IN-A6RO	STAD	TCGA	ITPSPS	DEG_SCF_FBW7_1	0.0833
p.A94T	DO51740	STAD	ICGC	ITPSPS	DEG_SCF_FBW7_1	0.0833
p.L99P	TCGA-MI-A75H	LIHC	TCGA	ITPSPS	DEG_SCF_FBW7_1	0.2222
p.L99P	DO49710	LIHC	ICGC	ITPSPS	DEG_SCF_FBW7_1	0.2222
p.L99P	SIDM00960	Colorectal Carcinoma	GDSC	ITPSPS	DEG_SCF_FBW7_1	0.2222
p.L99P	ACH-000798	Colon/Colorectal Cancer	CCLE	ITPSPS	DEG_SCF_FBW7_1	0.2222
p.P107T	TCGA-MP-A4T4	LUAD	TCGA	ITPSPS	DEG_SCF_FBW7_1	0.5919
p.P107T	DO48736	LIRI	ICGC	ITPSPS	DEG_SCF_FBW7_1	0.5919
p.P107T	DO45357	LUAD	ICGC	ITPSPS	DEG_SCF_FBW7_1	0.5919
p.P107H	TCGA-MP-A4T4	LUAD	TCGA	ITPSPS	DEG_SCF_FBW7_1	0.6583
p.P107H	DO45357	LUAD	ICGC	ITPSPS	DEG_SCF_FBW7_1	0.6583
p.I113F	DO49193	PACA	ICGC	ITPSPS	DEG_SCF_FBW7_1	0.1944
p.S111F	DO218849	SKCA	ICGC	ITPSPS	DEG_SCF_FBW7_1	0.25
p.A94D	SIDM00681	Colorectal Carcinoma	GDSC	ITPSPS	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ITPSPS

Degron related mutations and impact score

Drug responses associated with SPRY3 mutations

All proteins holding degron of ITPSPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43610	Protein sprouty homolog 3	DEG_SCF_FBW7_1	103:108	ITPSPS	FBXW7	0.9616	More...