DegronMD - O43610(SPRY3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G109C	TCGA-37-4135	LUSC	TCGA	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.3056
p.G109C	TCGA-37-4135	LUSC	TCGA	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation rewiring degron network	0.1389
p.G109C	DO26806	LUSC	ICGC	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.3056
p.G109C	DO26806	LUSC	ICGC	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation rewiring degron network	0.1389
p.Q97E	TCGA-4J-AA1J	CESC	TCGA	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.1667
p.Q97E	DO219718	CESC	ICGC	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.1667
p.R98M	TCGA-56-1622	LUSC	TCGA	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.1944
p.R98M	DO26461	LUSC	ICGC	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.1944
p.R114L	TCGA-70-6722	LUSC	TCGA	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.1667
p.R114L	TCGA-70-6722	LUSC	TCGA	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation rewiring degron network	0.2778
p.R114L	DO27755	LUSC	ICGC	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.1667
p.R114L	DO27755	LUSC	ICGC	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation rewiring degron network	0.2778
p.R114Q	TCGA-AG-3892	READ	TCGA	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.1667
p.R114Q	TCGA-AG-3892	READ	TCGA	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation rewiring degron network	0.2778
p.R114Q	DO36394	READ	ICGC	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.1667
p.R114Q	DO36394	READ	ICGC	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation rewiring degron network	0.2778
p.R114Q	SIDM02018	Colorectal Carcinoma	GDSC	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.1667
p.R114Q	SIDM02018	Colorectal Carcinoma	GDSC	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation rewiring degron network	0.2778
p.R114Q	SIDM00451	T-Lymphoblastic Leukemia	GDSC	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.1667
p.R114Q	SIDM00451	T-Lymphoblastic Leukemia	GDSC	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation rewiring degron network	0.2778
p.E134D	TCGA-AX-A0J1	UCEC	TCGA	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation rewiring degron network	0.0556
p.E134D	DO231104	LUSC	ICGC	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation rewiring degron network	0.0556
p.E134D	DO41199	UCEC	ICGC	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation rewiring degron network	0.0556
p.S108L	TCGA-BF-A1Q0	SKCM	TCGA	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation altering degron motif	0.7667
p.S108L	TCGA-FW-A5DY	SKCM	TCGA	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation altering degron motif	0.7667
p.S108L	DO47257	SKCM	ICGC	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation altering degron motif	0.7667
p.S108L	DO47374	SKCM	ICGC	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation altering degron motif	0.7667
p.G109V	TCGA-CM-5864	COAD	TCGA	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.3056
p.G109V	TCGA-CM-5864	COAD	TCGA	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation rewiring degron network	0.1389
p.G109V	DO8690	COAD	ICGC	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.3056
p.G109V	DO8690	COAD	ICGC	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation rewiring degron network	0.1389
p.G118A	TCGA-D1-A1NU	UCEC	TCGA	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation altering degron motif	0.6429
p.G118A	DO43811	UCEC	ICGC	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation altering degron motif	0.6429
p.G120R	TCGA-DX-A6Z2	SARC	TCGA	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation altering degron motif	0.6457
p.G120R	DO220019	SARC	ICGC	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation altering degron motif	0.6457
p.A94T	TCGA-IN-A6RO	STAD	TCGA	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.0833
p.A94T	DO51740	STAD	ICGC	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.0833
p.L99P	TCGA-MI-A75H	LIHC	TCGA	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.2222
p.L99P	DO49710	LIHC	ICGC	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.2222
p.L99P	SIDM00960	Colorectal Carcinoma	GDSC	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.2222
p.L99P	ACH-000798	Colon/Colorectal Cancer	CCLE	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.2222
p.P107T	TCGA-MP-A4T4	LUAD	TCGA	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation altering degron motif	0.5919
p.P107T	DO48736	LIRI	ICGC	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation altering degron motif	0.5919
p.P107T	DO45357	LUAD	ICGC	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation altering degron motif	0.5919
p.P107H	TCGA-MP-A4T4	LUAD	TCGA	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation altering degron motif	0.6583
p.P107H	DO45357	LUAD	ICGC	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation altering degron motif	0.6583
p.G118E	DO220906	MELA	ICGC	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation altering degron motif	0.6087
p.I113F	DO49193	PACA	ICGC	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.1944
p.I113F	DO49193	PACA	ICGC	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation rewiring degron network	0.25
p.S111F	DO218849	SKCA	ICGC	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.25
p.S111F	DO218849	SKCA	ICGC	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation rewiring degron network	0.1944
p.A119V	SIDM00731	Small Cell Lung Carcinoma	GDSC	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation altering degron motif	0.6936
p.A119V	ACH-000399	Lung Cancer	CCLE	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation altering degron motif	0.6936
p.A94D	SIDM00681	Colorectal Carcinoma	GDSC	ITPSPS	DEG_SCF_FBW7_1	103:108	Mutation rewiring degron network	0.0833
p.E134Q	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation rewiring degron network	0.0556
p.E134Q	ACH-000916	Lung Cancer	CCLE	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation rewiring degron network	0.0556
p.H122N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation altering degron motif	0.6312
p.H122N	ACH-001127	Leukemia	CCLE	QPGAGVHPK	DEG_SIAH_1	116:124	Mutation altering degron motif	0.6312

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPRY3

UniProt ID: O43610

Entrez ID: 10251

Protein name: Protein sprouty homolog 3 (Spry-3) (Sprouty RTK signaling antagonist 3) (Sprouty3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPRY3 in