DegronMD

Uniprot ID: O43610

Source protein: Protein sprouty homolog 3

Source gene: SPRY3

Class: DEG_SIAH_1

Location: 116:124

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9522

ASA_SCORE: 73.6333

COIL: 0.8962

CONS_SCORE: 0.3558

DSS_SCORE: 0.6404

HELIX: 0.0437

FCONS_SCORE: 1.0326

RIG_SCORE: 0.6116

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G109C	TCGA-37-4135	LUSC	TCGA	QPGAGVHPK	DEG_SIAH_1	0.1389
p.G109C	DO26806	LUSC	ICGC	QPGAGVHPK	DEG_SIAH_1	0.1389
p.R114L	TCGA-70-6722	LUSC	TCGA	QPGAGVHPK	DEG_SIAH_1	0.2778
p.R114L	DO27755	LUSC	ICGC	QPGAGVHPK	DEG_SIAH_1	0.2778
p.R114Q	TCGA-AG-3892	READ	TCGA	QPGAGVHPK	DEG_SIAH_1	0.2778
p.R114Q	DO36394	READ	ICGC	QPGAGVHPK	DEG_SIAH_1	0.2778
p.R114Q	SIDM02018	Colorectal Carcinoma	GDSC	QPGAGVHPK	DEG_SIAH_1	0.2778
p.R114Q	SIDM00451	T-Lymphoblastic Leukemia	GDSC	QPGAGVHPK	DEG_SIAH_1	0.2778
p.E134D	TCGA-AX-A0J1	UCEC	TCGA	QPGAGVHPK	DEG_SIAH_1	0.0556
p.E134D	DO231104	LUSC	ICGC	QPGAGVHPK	DEG_SIAH_1	0.0556
p.E134D	DO41199	UCEC	ICGC	QPGAGVHPK	DEG_SIAH_1	0.0556
p.G109V	TCGA-CM-5864	COAD	TCGA	QPGAGVHPK	DEG_SIAH_1	0.1389
p.G109V	DO8690	COAD	ICGC	QPGAGVHPK	DEG_SIAH_1	0.1389
p.G118A	TCGA-D1-A1NU	UCEC	TCGA	QPGAGVHPK	DEG_SIAH_1	0.6429
p.G118A	DO43811	UCEC	ICGC	QPGAGVHPK	DEG_SIAH_1	0.6429
p.G120R	TCGA-DX-A6Z2	SARC	TCGA	QPGAGVHPK	DEG_SIAH_1	0.6457
p.G120R	DO220019	SARC	ICGC	QPGAGVHPK	DEG_SIAH_1	0.6457
p.G118E	DO220906	MELA	ICGC	QPGAGVHPK	DEG_SIAH_1	0.6087
p.I113F	DO49193	PACA	ICGC	QPGAGVHPK	DEG_SIAH_1	0.25
p.S111F	DO218849	SKCA	ICGC	QPGAGVHPK	DEG_SIAH_1	0.1944
p.A119V	SIDM00731	Small Cell Lung Carcinoma	GDSC	QPGAGVHPK	DEG_SIAH_1	0.6936
p.A119V	ACH-000399	Lung Cancer	CCLE	QPGAGVHPK	DEG_SIAH_1	0.6936
p.E134Q	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	QPGAGVHPK	DEG_SIAH_1	0.0556
p.E134Q	ACH-000916	Lung Cancer	CCLE	QPGAGVHPK	DEG_SIAH_1	0.0556
p.H122N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	QPGAGVHPK	DEG_SIAH_1	0.6312
p.H122N	ACH-001127	Leukemia	CCLE	QPGAGVHPK	DEG_SIAH_1	0.6312

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43610	Protein sprouty homolog 3	DEG_SIAH_1	116:124	QPGAGVHPK	SIAH1,SIAH2,SIAH3	0.9522	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons