DegronMD

Uniprot ID: Q9NPZ5

Source protein: Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2

Source gene: B3GAT2

Class: DEG_SCF_FBW7_1

Location: 85:90

E3 ligase: FBXW7

DEGRON score: 0.5578

ASA_SCORE: 35.7667

COIL: 0.7497

CONS_SCORE: 0.6863

DSS_SCORE: 0.4698

HELIX: 0.0185

FCONS_SCORE: 1.2077

RIG_SCORE: 0.7575

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T88A	TCGA-2W-A8YY	CESC	TCGA	ITPTYS	DEG_SCF_FBW7_1	0.6028
p.T88A	DO223732	CESC	ICGC	ITPTYS	DEG_SCF_FBW7_1	0.6028
p.E76K	TCGA-86-8669	LUAD	TCGA	ITPTYS	DEG_SCF_FBW7_1	0.0833
p.E76K	DO25574	LUAD	ICGC	ITPTYS	DEG_SCF_FBW7_1	0.0833
p.P75Q	TCGA-ER-A19P	SKCM	TCGA	ITPTYS	DEG_SCF_FBW7_1	0.0556
p.P75Q	DO47623	SKCM	ICGC	ITPTYS	DEG_SCF_FBW7_1	0.0556
p.Q94H	TCGA-FD-A3SO	BLCA	TCGA	ITPTYS	DEG_SCF_FBW7_1	0.2222
p.Q94H	DO569	BLCA	ICGC	ITPTYS	DEG_SCF_FBW7_1	0.2222
p.Y83F	DO6350	CLLE	ICGC	ITPTYS	DEG_SCF_FBW7_1	0.2778
p.A96G	DO233840	GACA	ICGC	ITPTYS	DEG_SCF_FBW7_1	0.1667
p.R91H	DO229248	THCA	ICGC	ITPTYS	DEG_SCF_FBW7_1	0.3056
p.T99A	SIDM00358	Gastric Carcinoma	GDSC	ITPTYS	DEG_SCF_FBW7_1	0.0833
p.T99A	ACH-000144	Gastric Cancer	CCLE	ITPTYS	DEG_SCF_FBW7_1	0.0833
p.T99A	RERF-GC-1B	stomach	COSMIC	ITPTYS	DEG_SCF_FBW7_1	0.0833
p.A84D	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	ITPTYS	DEG_SCF_FBW7_1	0.3056
p.A84D	ACH-000929	Lung Cancer	CCLE	ITPTYS	DEG_SCF_FBW7_1	0.3056
p.A84D	NCI-H2110	lung	COSMIC	ITPTYS	DEG_SCF_FBW7_1	0.3056
p.V93L	SIDM01387	Small Cell Lung Carcinoma	GDSC	ITPTYS	DEG_SCF_FBW7_1	0.25
p.V93L	ACH-000921	Lung Cancer	CCLE	ITPTYS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NPZ5	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2	DEG_SCF_FBW7_1	85:90	ITPTYS	FBXW7	0.5578	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons