DegronMD - Q9NPZ5(B3GAT2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T88A	TCGA-2W-A8YY	CESC	TCGA	ITPTYS	DEG_SCF_FBW7_1	85:90	Mutation altering degron motif	0.6028
p.T88A	DO223732	CESC	ICGC	ITPTYS	DEG_SCF_FBW7_1	85:90	Mutation altering degron motif	0.6028
p.E76K	TCGA-86-8669	LUAD	TCGA	ITPTYS	DEG_SCF_FBW7_1	85:90	Mutation rewiring degron network	0.0833
p.E76K	DO25574	LUAD	ICGC	ITPTYS	DEG_SCF_FBW7_1	85:90	Mutation rewiring degron network	0.0833
p.T144K	TCGA-91-8499	LUAD	TCGA	STHLHVPTP	DEG_COP1_1	137:145	Mutation altering degron motif	0.7306
p.T144K	DO45349	LUAD	ICGC	STHLHVPTP	DEG_COP1_1	137:145	Mutation altering degron motif	0.7306
p.P75Q	TCGA-ER-A19P	SKCM	TCGA	ITPTYS	DEG_SCF_FBW7_1	85:90	Mutation rewiring degron network	0.0556
p.P75Q	DO47623	SKCM	ICGC	ITPTYS	DEG_SCF_FBW7_1	85:90	Mutation rewiring degron network	0.0556
p.Q94H	TCGA-FD-A3SO	BLCA	TCGA	ITPTYS	DEG_SCF_FBW7_1	85:90	Mutation rewiring degron network	0.2222
p.Q94H	DO569	BLCA	ICGC	ITPTYS	DEG_SCF_FBW7_1	85:90	Mutation rewiring degron network	0.2222
p.Y83F	DO6350	CLLE	ICGC	ITPTYS	DEG_SCF_FBW7_1	85:90	Mutation rewiring degron network	0.2778
p.A96G	DO233840	GACA	ICGC	ITPTYS	DEG_SCF_FBW7_1	85:90	Mutation rewiring degron network	0.1667
p.R128H	DO232761	PBCA	ICGC	STHLHVPTP	DEG_COP1_1	137:145	Mutation rewiring degron network	0.0833
p.R91H	DO229248	THCA	ICGC	ITPTYS	DEG_SCF_FBW7_1	85:90	Mutation rewiring degron network	0.3056
p.T99A	SIDM00358	Gastric Carcinoma	GDSC	ITPTYS	DEG_SCF_FBW7_1	85:90	Mutation rewiring degron network	0.0833
p.T99A	ACH-000144	Gastric Cancer	CCLE	ITPTYS	DEG_SCF_FBW7_1	85:90	Mutation rewiring degron network	0.0833
p.T99A	RERF-GC-1B	stomach	COSMIC	ITPTYS	DEG_SCF_FBW7_1	85:90	Mutation rewiring degron network	0.0833
p.A84D	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	ITPTYS	DEG_SCF_FBW7_1	85:90	Mutation rewiring degron network	0.3056
p.A84D	ACH-000929	Lung Cancer	CCLE	ITPTYS	DEG_SCF_FBW7_1	85:90	Mutation rewiring degron network	0.3056
p.A84D	NCI-H2110	lung	COSMIC	ITPTYS	DEG_SCF_FBW7_1	85:90	Mutation rewiring degron network	0.3056
p.R132Q	SIDM00150	Colorectal Carcinoma	GDSC	STHLHVPTP	DEG_COP1_1	137:145	Mutation rewiring degron network	0.1944
p.R132Q	ACH-000969	Colon/Colorectal Cancer	CCLE	STHLHVPTP	DEG_COP1_1	137:145	Mutation rewiring degron network	0.1944
p.V93L	SIDM01387	Small Cell Lung Carcinoma	GDSC	ITPTYS	DEG_SCF_FBW7_1	85:90	Mutation rewiring degron network	0.25
p.V93L	ACH-000921	Lung Cancer	CCLE	ITPTYS	DEG_SCF_FBW7_1	85:90	Mutation rewiring degron network	0.25
p.A133V	ACH-001484	Leukemia	CCLE	STHLHVPTP	DEG_COP1_1	137:145	Mutation rewiring degron network	0.2222
p.A133V	ACH-001485	Leukemia	CCLE	STHLHVPTP	DEG_COP1_1	137:145	Mutation rewiring degron network	0.2222
p.R130H	RS4-11	haematopoietic and lymphoid tissue	COSMIC	STHLHVPTP	DEG_COP1_1	137:145	Mutation rewiring degron network	0.1389
p.T129N	BONNA-12	haematopoietic and lymphoid tissue	COSMIC	STHLHVPTP	DEG_COP1_1	137:145	Mutation rewiring degron network	0.1111
p.R143W	HCT-15	large intestine	COSMIC	STHLHVPTP	DEG_COP1_1	137:145	Mutation altering degron motif	0.8634
p.L139P	NCI-H740	lung	COSMIC	STHLHVPTP	DEG_COP1_1	137:145	Mutation altering degron motif	0.7582

Kaplan plot for B3GAT2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

B3GAT2

UniProt ID: Q9NPZ5

Entrez ID: 135152

Protein name: Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 2) (GlcAT-D) (UDP-glucuronosyltransferase S) (GlcAT-S) (Glucuronosyltransferase S)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for B3GAT2 in