DegronMD

Uniprot ID: Q9NPZ5

Source protein: Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2

Source gene: B3GAT2

Class: DEG_COP1_1

Location: 137:145

E3 ligase: COP1

DEGRON score: 0.6703

ASA_SCORE: 53.9667

COIL: 0.576

CONS_SCORE: 0.5659

DSS_SCORE: 0.5074

HELIX: 0.0244

FCONS_SCORE: 1.1716

RIG_SCORE: 0.6895

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T144K	TCGA-91-8499	LUAD	TCGA	STHLHVPTP	DEG_COP1_1	0.7306
p.T144K	DO45349	LUAD	ICGC	STHLHVPTP	DEG_COP1_1	0.7306
p.R128H	DO232761	PBCA	ICGC	STHLHVPTP	DEG_COP1_1	0.0833
p.R132Q	SIDM00150	Colorectal Carcinoma	GDSC	STHLHVPTP	DEG_COP1_1	0.1944
p.R132Q	ACH-000969	Colon/Colorectal Cancer	CCLE	STHLHVPTP	DEG_COP1_1	0.1944
p.A133V	ACH-001484	Leukemia	CCLE	STHLHVPTP	DEG_COP1_1	0.2222
p.A133V	ACH-001485	Leukemia	CCLE	STHLHVPTP	DEG_COP1_1	0.2222
p.R130H	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	STHLHVPTP	DEG_COP1_1	0.1389
p.T129N	BONNA-12	haematopoietic_and_lymphoid_tissue	COSMIC	STHLHVPTP	DEG_COP1_1	0.1111
p.R143W	HCT-15	large_intestine	COSMIC	STHLHVPTP	DEG_COP1_1	0.8634
p.L139P	NCI-H740	lung	COSMIC	STHLHVPTP	DEG_COP1_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NPZ5	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2	DEG_COP1_1	137:145	STHLHVPTP	COP1	0.6703	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons