DegronMD

Uniprot ID: P46821

Source protein: Microtubule-associated protein 1B

Source gene: MAP1B

Class: DEG_SCF_FBW7_1

Location: 2048:2055

E3 ligase: FBXW7

DEGRON score: 0.9848

ASA_SCORE: 94.7375

COIL: 0.848

CONS_SCORE: 0.4899

DSS_SCORE: 0.4007

HELIX: 0.0408

FCONS_SCORE: 1.0334

RIG_SCORE: 0.7606

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2049S	TCGA-55-A490	LUAD	TCGA	ITRTPQAS	DEG_SCF_FBW7_1	0.6005
p.T2049S	DO24596	LUAD	ICGC	ITRTPQAS	DEG_SCF_FBW7_1	0.6005
p.E2046D	TCGA-AA-3984	COAD	TCGA	ITRTPQAS	DEG_SCF_FBW7_1	0.2778
p.E2046D	TCGA-AG-A002	READ	TCGA	ITRTPQAS	DEG_SCF_FBW7_1	0.2778
p.E2046D	TCGA-E6-A1LX	UCEC	TCGA	ITRTPQAS	DEG_SCF_FBW7_1	0.2778
p.E2046D	DO9002	COAD	ICGC	ITRTPQAS	DEG_SCF_FBW7_1	0.2778
p.E2046D	DO41020	UCEC	ICGC	ITRTPQAS	DEG_SCF_FBW7_1	0.2778
p.E2060D	TCGA-B0-5080	KIRC	TCGA	ITRTPQAS	DEG_SCF_FBW7_1	0.1944
p.E2060D	TCGA-D1-A17Q	UCEC	TCGA	ITRTPQAS	DEG_SCF_FBW7_1	0.1944
p.E2060D	DO18154	KIRC	ICGC	ITRTPQAS	DEG_SCF_FBW7_1	0.1944
p.E2060D	DO41903	UCEC	ICGC	ITRTPQAS	DEG_SCF_FBW7_1	0.1944
p.E2043K	TCGA-FW-A3R5	SKCM	TCGA	ITRTPQAS	DEG_SCF_FBW7_1	0.1944
p.E2043K	DO228114	EOPC	ICGC	ITRTPQAS	DEG_SCF_FBW7_1	0.1944
p.E2043K	DO37406	SKCM	ICGC	ITRTPQAS	DEG_SCF_FBW7_1	0.1944
p.Q2053H	TCGA-IB-7651	PAAD	TCGA	ITRTPQAS	DEG_SCF_FBW7_1	0.647
p.Q2053H	DO46657	PAAD	ICGC	ITRTPQAS	DEG_SCF_FBW7_1	0.647
p.T2056A	TCGA-RS-A6TP	HNSC	TCGA	ITRTPQAS	DEG_SCF_FBW7_1	0.3056
p.T2056A	DO219062	HNSC	ICGC	ITRTPQAS	DEG_SCF_FBW7_1	0.3056
p.S2055F	DO222695	ESCA	ICGC	ITRTPQAS	DEG_SCF_FBW7_1	0.9093
p.C2041F	DO229045	LICA	ICGC	ITRTPQAS	DEG_SCF_FBW7_1	0.1389
p.T2051A	DO232761	PBCA	ICGC	ITRTPQAS	DEG_SCF_FBW7_1	0.825
p.Y2040C	SIDM01608	Endometrial Carcinoma	GDSC	ITRTPQAS	DEG_SCF_FBW7_1	0.5556
p.Y2040C	ACH-000990	Endometrial/Uterine Cancer	CCLE	ITRTPQAS	DEG_SCF_FBW7_1	0.5556
p.E2060K	ACH-001991	Primary	CCLE	ITRTPQAS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46821	Microtubule-associated protein 1B	DEG_SCF_FBW7_1	2048:2055	ITRTPQAS	FBXW7	0.9848	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons