DegronMD

Uniprot ID: Q8IUI8

Source protein: Cytokine receptor-like factor 3

Source gene: CRLF3

Class: LIG_APCC_ABBA_1

Location: 235:240

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8273

ASA_SCORE: 55.1833

COIL: 0.405

CONS_SCORE: 0.485

DSS_SCORE: 0.096

HELIX: 0.0067

FCONS_SCORE: 0.878

RIG_SCORE: 0.9208

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R248T	TCGA-60-2698	LUSC	TCGA	IVLHID	LIG_APCC_ABBA_1	0.1111
p.V243I	TCGA-D1-A103	UCEC	TCGA	IVLHID	LIG_APCC_ABBA_1	0.25
p.F234L	TCGA-DD-AADK	LIHC	TCGA	IVLHID	LIG_APCC_ABBA_1	0.3056
p.H238L	TCGA-SX-A7SR	KIRP	TCGA	IVLHID	LIG_APCC_ABBA_1	0.7313
p.L230V	DO44242	BRCA	ICGC	IVLHID	LIG_APCC_ABBA_1	0.1944
p.V228L	SIDM00985	Burkitt's Lymphoma	GDSC	IVLHID	LIG_APCC_ABBA_1	0.1389
p.V236I	SIDM00971	Breast Carcinoma	GDSC	IVLHID	LIG_APCC_ABBA_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IUI8	Cytokine receptor-like factor 3	LIG_APCC_ABBA_1	235:240	IVLHID	APC,CDC20,FZR1	0.8273	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons