DegronMD

Uniprot ID: Q9BQK8

Source protein: Phosphatidate phosphatase LPIN3

Source gene: LPIN3

Class: LIG_APCC_ABBA_1

Location: 200:205

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9929

ASA_SCORE: 64.0667

COIL: 0.8392

CONS_SCORE: 0.2685

DSS_SCORE: 0.6322

HELIX: 0.083

FCONS_SCORE: 1.0141

RIG_SCORE: 0.6865

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E207K	TCGA-59-2349	OV	TCGA	IYPYSD	LIG_APCC_ABBA_1	0.2778
p.E207K	DO28621	OV	ICGC	IYPYSD	LIG_APCC_ABBA_1	0.2778
p.I200V	TCGA-BR-7197	STAD	TCGA	IYPYSD	LIG_APCC_ABBA_1	0.5965
p.I200V	DO38839	STAD	ICGC	IYPYSD	LIG_APCC_ABBA_1	0.5965
p.D200A	SIDM01265	Plasma Cell Myeloma	GDSC	IYPYSD	LIG_APCC_ABBA_1	0.7793
p.D200A	SIDM00672	Hepatocellular Carcinoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	0.7793
p.D200A	SIDM00773	Non-Cancerous	GDSC	IYPYSD	LIG_APCC_ABBA_1	0.7793
p.D200A	SIDM00087	Plasma Cell Myeloma	GDSC	IYPYSD	LIG_APCC_ABBA_1	0.7793
p.D200A	SIDM00633	Breast Carcinoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	0.7793
p.D200A	SIDM00844	Burkitt's Lymphoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	0.7793
p.D200A	SIDM00793	Burkitt's Lymphoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	0.7793
p.D200A	SIDM00774	Breast Carcinoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	0.7793
p.D200A	SIDM01664	Prostate Carcinoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	0.7793
p.E191K	SIDM01090	Colorectal Carcinoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	0.0833
p.E191K	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	0.0833
p.E191K	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	0.0833
p.Q197R	SIDM00554	Ovarian Carcinoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	0.25
p.Q197R	SIDM01660	Kidney Carcinoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	0.25
p.Q197R	SIDM01622	Breast Carcinoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQK8	Phosphatidate phosphatase LPIN3	LIG_APCC_ABBA_1	200:205	IYPYSD	APC,CDC20,FZR1	0.9929	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons