DegronMD - Q9BQK8(LPIN3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E207K	TCGA-59-2349	OV	TCGA	IYPYSD	LIG_APCC_ABBA_1	200:205	Mutation rewiring degron network	0.2778
p.E207K	DO28621	OV	ICGC	IYPYSD	LIG_APCC_ABBA_1	200:205	Mutation rewiring degron network	0.2778
p.Y832H	TCGA-86-A4JF	LUAD	TCGA	WREPLPAVD	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.1667
p.Y832H	DO45317	LUAD	ICGC	WREPLPAVD	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.1667
p.S570I	TCGA-AP-A1DV	UCEC	TCGA	PPSTPPST	DEG_SCF_FBW7_1	580:587	Mutation rewiring degron network	0.0556
p.S570I	DO43186	UCEC	ICGC	PPSTPPST	DEG_SCF_FBW7_1	580:587	Mutation rewiring degron network	0.0556
p.L847I	TCGA-AX-A2HD	UCEC	TCGA	WREPLPAVD	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.3056
p.L847I	DO42608	UCEC	ICGC	WREPLPAVD	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.3056
p.A272V	TCGA-B0-5098	KIRC	TCGA	PSTPSTS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.1111
p.A272V	DO18938	KIRC	ICGC	PSTPSTS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.1111
p.I200V	TCGA-BR-7197	STAD	TCGA	IYPYSD	LIG_APCC_ABBA_1	200:205	Mutation altering degron motif	0.5965
p.I200V	DO38839	STAD	ICGC	IYPYSD	LIG_APCC_ABBA_1	200:205	Mutation altering degron motif	0.5965
p.V291M	TCGA-BR-8680	STAD	TCGA	PSTPSTS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.1944
p.V291M	DO47769	STAD	ICGC	PSTPSTS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.1944
p.K591N	TCGA-BS-A0UF	UCEC	TCGA	PPSTPPST	DEG_SCF_FBW7_1	580:587	Mutation substituting flanking lysine	0.3333
p.K591N	DO41488	UCEC	ICGC	PPSTPPST	DEG_SCF_FBW7_1	580:587	Mutation substituting flanking lysine	0.3333
p.A828T	TCGA-CD-A4MG	STAD	TCGA	WREPLPAVD	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.0556
p.A828T	DO48009	STAD	ICGC	WREPLPAVD	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.0556
p.P222T	TCGA-D3-A2J6	SKCM	TCGA	VRTPEPS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.1111
p.P222T	DO37901	SKCM	ICGC	VRTPEPS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.1111
p.S286F	TCGA-D3-A8GO	SKCM	TCGA	PSTPSTS	DEG_SCF_FBW7_1	280:286	Mutation altering degron motif	0.7982
p.S286F	DO51242	SKCM	ICGC	PSTPSTS	DEG_SCF_FBW7_1	280:286	Mutation altering degron motif	0.7982
p.S593F	TCGA-EE-A3JA	SKCM	TCGA	PPSTPPST	DEG_SCF_FBW7_1	580:587	Mutation rewiring degron network	0.1667
p.S593F	DO47625	SKCM	ICGC	PPSTPPST	DEG_SCF_FBW7_1	580:587	Mutation rewiring degron network	0.1667
p.V572A	TCGA-EO-A22R	UCEC	TCGA	PPSTPPST	DEG_SCF_FBW7_1	580:587	Mutation rewiring degron network	0.1111
p.V572A	DO42713	UCEC	ICGC	PPSTPPST	DEG_SCF_FBW7_1	580:587	Mutation rewiring degron network	0.1111
p.A240V	DO233052	GACA	ICGC	VRTPEPS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.2222
p.T589I	DO233254	GACA	ICGC	PPSTPPST	DEG_SCF_FBW7_1	580:587	Mutation rewiring degron network	0.2778
p.W246L	DO228461	LICA	ICGC	VRTPEPS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.0556
p.W246C	DO228461	LICA	ICGC	VRTPEPS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.0556
p.A828D	DO228589	LICA	ICGC	WREPLPAVD	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.0556
p.R277L	DO228978	LICA	ICGC	PSTPSTS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.25
p.P276S	DO220886	MELA	ICGC	PSTPSTS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.2222
p.I573V	DO222562	MELA	ICGC	PPSTPPST	DEG_SCF_FBW7_1	580:587	Mutation rewiring degron network	0.1389
p.P276L	DO222731	MELA	ICGC	PSTPSTS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.2222
p.S597F	DO229462	SKCA	ICGC	PPSTPPST	DEG_SCF_FBW7_1	580:587	Mutation blocking phosphorylation signal	0.5
p.V846M	SIDM01293	Colorectal Carcinoma	GDSC	WREPLPAVD	DEG_APCC_DBOX_1	838:846	Mutation altering degron motif	0.7208
p.D200A	SIDM01265	Plasma Cell Myeloma	GDSC	IYPYSD	LIG_APCC_ABBA_1	200:205	Mutation altering degron motif	0.7793
p.D200A	SIDM00672	Hepatocellular Carcinoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	200:205	Mutation altering degron motif	0.7793
p.D200A	SIDM00773	Non-Cancerous	GDSC	IYPYSD	LIG_APCC_ABBA_1	200:205	Mutation altering degron motif	0.7793
p.D200A	SIDM00087	Plasma Cell Myeloma	GDSC	IYPYSD	LIG_APCC_ABBA_1	200:205	Mutation altering degron motif	0.7793
p.D200A	SIDM00633	Breast Carcinoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	200:205	Mutation altering degron motif	0.7793
p.D200A	SIDM00844	Burkitt's Lymphoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	200:205	Mutation altering degron motif	0.7793
p.D200A	SIDM00793	Burkitt's Lymphoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	200:205	Mutation altering degron motif	0.7793
p.D200A	SIDM00774	Breast Carcinoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	200:205	Mutation altering degron motif	0.7793
p.D200A	SIDM01664	Prostate Carcinoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	200:205	Mutation altering degron motif	0.7793
p.E191K	SIDM01090	Colorectal Carcinoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	200:205	Mutation rewiring degron network	0.0833
p.E191K	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	200:205	Mutation rewiring degron network	0.0833
p.E191K	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	200:205	Mutation rewiring degron network	0.0833
p.A845T	SIDM01090	Colorectal Carcinoma	GDSC	WREPLPAVD	DEG_APCC_DBOX_1	838:846	Mutation altering degron motif	0.7139
p.A845T	RKO	large intestine	COSMIC	WREPLPAVD	DEG_APCC_DBOX_1	838:846	Mutation altering degron motif	0.7139
p.P238H	SIDM01218	Other Solid Cancers	GDSC	VRTPEPS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.2778
p.P238H	JEG-3	placenta	COSMIC	VRTPEPS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.2778
p.S227L	SIDM00854	Burkitt's Lymphoma	GDSC	VRTPEPS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.25
p.S227L	SIDM01118	Small Cell Lung Carcinoma	GDSC	VRTPEPS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.25
p.Q197R	SIDM00554	Ovarian Carcinoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	200:205	Mutation rewiring degron network	0.25
p.Q197R	SIDM01660	Kidney Carcinoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	200:205	Mutation rewiring degron network	0.25
p.Q197R	SIDM01622	Breast Carcinoma	GDSC	IYPYSD	LIG_APCC_ABBA_1	200:205	Mutation rewiring degron network	0.25
p.R278W	SIDM01689	B-Lymphoblastic Leukemia	GDSC	PSTPSTS	DEG_SCF_FBW7_1	280:286	Mutation rewiring degron network	0.2778
p.L847V	ACH-000436	Myeloma	CCLE	WREPLPAVD	DEG_APCC_DBOX_1	838:846	Mutation rewiring degron network	0.3056
p.A844T	ACH-000943	Colon/Colorectal Cancer	CCLE	WREPLPAVD	DEG_APCC_DBOX_1	838:846	Mutation altering degron motif	0.6028
p.A844T	RKO	large intestine	COSMIC	WREPLPAVD	DEG_APCC_DBOX_1	838:846	Mutation altering degron motif	0.6028
p.S281N	ACH-001190	Skin Cancer	CCLE	PSTPSTS	DEG_SCF_FBW7_1	280:286	Mutation altering degron motif	0.5958
p.P237H	ACH-001530	Endometrial/Uterine Cancer	CCLE	VRTPEPS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.3056
p.P237H	JEG-3	placenta	COSMIC	VRTPEPS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.3056
p.P233L	ACH-001750	Sarcoma	CCLE	VRTPEPS	DEG_SCF_FBW7_1	230:236	Mutation altering degron motif	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LPIN3

UniProt ID: Q9BQK8

Entrez ID: 64900

Protein name: Phosphatidate phosphatase LPIN3 (EC 3.1.3.4) (Lipin-3) (Lipin-3-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LPIN3 in