DegronMD

Uniprot ID: Q9BQK8

Source protein: Phosphatidate phosphatase LPIN3

Source gene: LPIN3

Class: DEG_SCF_FBW7_1

Location: 230:236

E3 ligase: FBXW7

DEGRON score: 0.9066

ASA_SCORE: 93.8429

COIL: 0.9001

CONS_SCORE: 0.2623

DSS_SCORE: 0.6485

HELIX: 0.0303

FCONS_SCORE: 1.0789

RIG_SCORE: 0.6552

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P222T	TCGA-D3-A2J6	SKCM	TCGA	VRTPEPS	DEG_SCF_FBW7_1	0.1111
p.P222T	DO37901	SKCM	ICGC	VRTPEPS	DEG_SCF_FBW7_1	0.1111
p.A240V	DO233052	GACA	ICGC	VRTPEPS	DEG_SCF_FBW7_1	0.2222
p.W246L	DO228461	LICA	ICGC	VRTPEPS	DEG_SCF_FBW7_1	0.0556
p.W246C	DO228461	LICA	ICGC	VRTPEPS	DEG_SCF_FBW7_1	0.0556
p.P238H	SIDM01218	Other Solid Cancers	GDSC	VRTPEPS	DEG_SCF_FBW7_1	0.2778
p.P238H	JEG-3	placenta	COSMIC	VRTPEPS	DEG_SCF_FBW7_1	0.2778
p.S227L	SIDM00854	Burkitt's Lymphoma	GDSC	VRTPEPS	DEG_SCF_FBW7_1	0.25
p.S227L	SIDM01118	Small Cell Lung Carcinoma	GDSC	VRTPEPS	DEG_SCF_FBW7_1	0.25
p.P237H	ACH-001530	Endometrial/Uterine Cancer	CCLE	VRTPEPS	DEG_SCF_FBW7_1	0.3056
p.P237H	JEG-3	placenta	COSMIC	VRTPEPS	DEG_SCF_FBW7_1	0.3056
p.P233L	ACH-001750	Sarcoma	CCLE	VRTPEPS	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQK8	Phosphatidate phosphatase LPIN3	DEG_SCF_FBW7_1	230:236	VRTPEPS	FBXW7	0.9066	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons