DegronMD

Uniprot ID: Q9BQK8

Source protein: Phosphatidate phosphatase LPIN3

Source gene: LPIN3

Class: DEG_SCF_FBW7_1

Location: 280:286

E3 ligase: FBXW7

DEGRON score: 0.9984

ASA_SCORE: 76.3857

COIL: 0.8601

CONS_SCORE: 0.2576

DSS_SCORE: 0.7661

HELIX: 0.0424

FCONS_SCORE: 1.0883

RIG_SCORE: 0.5518

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A272V	TCGA-B0-5098	KIRC	TCGA	PSTPSTS	DEG_SCF_FBW7_1	0.1111
p.A272V	DO18938	KIRC	ICGC	PSTPSTS	DEG_SCF_FBW7_1	0.1111
p.V291M	TCGA-BR-8680	STAD	TCGA	PSTPSTS	DEG_SCF_FBW7_1	0.1944
p.V291M	DO47769	STAD	ICGC	PSTPSTS	DEG_SCF_FBW7_1	0.1944
p.S286F	TCGA-D3-A8GO	SKCM	TCGA	PSTPSTS	DEG_SCF_FBW7_1	0.7982
p.S286F	DO51242	SKCM	ICGC	PSTPSTS	DEG_SCF_FBW7_1	0.7982
p.R277L	DO228978	LICA	ICGC	PSTPSTS	DEG_SCF_FBW7_1	0.25
p.P276S	DO220886	MELA	ICGC	PSTPSTS	DEG_SCF_FBW7_1	0.2222
p.P276L	DO222731	MELA	ICGC	PSTPSTS	DEG_SCF_FBW7_1	0.2222
p.R278W	SIDM01689	B-Lymphoblastic Leukemia	GDSC	PSTPSTS	DEG_SCF_FBW7_1	0.2778
p.S281N	ACH-001190	Skin Cancer	CCLE	PSTPSTS	DEG_SCF_FBW7_1	0.5958

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQK8	Phosphatidate phosphatase LPIN3	DEG_SCF_FBW7_1	280:286	PSTPSTS	FBXW7	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons