DegronMD

Uniprot ID: Q9BQK8

Source protein: Phosphatidate phosphatase LPIN3

Source gene: LPIN3

Class: DEG_SCF_FBW7_1

Location: 580:587

E3 ligase: FBXW7

DEGRON score: 0.8657

ASA_SCORE: 87.25

COIL: 0.9651

CONS_SCORE: 0.2349

DSS_SCORE: 0.6567

HELIX: 0.0161

FCONS_SCORE: 0.5699

RIG_SCORE: 0.5547

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S570I	TCGA-AP-A1DV	UCEC	TCGA	PPSTPPST	DEG_SCF_FBW7_1	0.0556
p.S570I	DO43186	UCEC	ICGC	PPSTPPST	DEG_SCF_FBW7_1	0.0556
p.K591N	TCGA-BS-A0UF	UCEC	TCGA	PPSTPPST	DEG_SCF_FBW7_1	0.3333
p.K591N	DO41488	UCEC	ICGC	PPSTPPST	DEG_SCF_FBW7_1	0.3333
p.S593F	TCGA-EE-A3JA	SKCM	TCGA	PPSTPPST	DEG_SCF_FBW7_1	0.1667
p.S593F	DO47625	SKCM	ICGC	PPSTPPST	DEG_SCF_FBW7_1	0.1667
p.V572A	TCGA-EO-A22R	UCEC	TCGA	PPSTPPST	DEG_SCF_FBW7_1	0.1111
p.V572A	DO42713	UCEC	ICGC	PPSTPPST	DEG_SCF_FBW7_1	0.1111
p.T589I	DO233254	GACA	ICGC	PPSTPPST	DEG_SCF_FBW7_1	0.2778
p.I573V	DO222562	MELA	ICGC	PPSTPPST	DEG_SCF_FBW7_1	0.1389
p.S597F	DO229462	SKCA	ICGC	PPSTPPST	DEG_SCF_FBW7_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQK8	Phosphatidate phosphatase LPIN3	DEG_SCF_FBW7_1	580:587	PPSTPPST	FBXW7	0.8657	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons