DegronMD

Uniprot ID: Q9BQK8

Source protein: Phosphatidate phosphatase LPIN3

Source gene: LPIN3

Class: DEG_APCC_DBOX_1

Location: 838:846

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8889

ASA_SCORE: 73.0778

COIL: 0.8956

CONS_SCORE: 0.4122

DSS_SCORE: 0.2954

HELIX: 0.0219

FCONS_SCORE: 1.0438

RIG_SCORE: 0.839

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y832H	TCGA-86-A4JF	LUAD	TCGA	WREPLPAVD	DEG_APCC_DBOX_1	0.1667
p.Y832H	DO45317	LUAD	ICGC	WREPLPAVD	DEG_APCC_DBOX_1	0.1667
p.L847I	TCGA-AX-A2HD	UCEC	TCGA	WREPLPAVD	DEG_APCC_DBOX_1	0.3056
p.L847I	DO42608	UCEC	ICGC	WREPLPAVD	DEG_APCC_DBOX_1	0.3056
p.A828T	TCGA-CD-A4MG	STAD	TCGA	WREPLPAVD	DEG_APCC_DBOX_1	0.0556
p.A828T	DO48009	STAD	ICGC	WREPLPAVD	DEG_APCC_DBOX_1	0.0556
p.A828D	DO228589	LICA	ICGC	WREPLPAVD	DEG_APCC_DBOX_1	0.0556
p.V846M	SIDM01293	Colorectal Carcinoma	GDSC	WREPLPAVD	DEG_APCC_DBOX_1	0.7208
p.A845T	SIDM01090	Colorectal Carcinoma	GDSC	WREPLPAVD	DEG_APCC_DBOX_1	0.7139
p.A845T	RKO	large_intestine	COSMIC	WREPLPAVD	DEG_APCC_DBOX_1	0.7139
p.L847V	ACH-000436	Myeloma	CCLE	WREPLPAVD	DEG_APCC_DBOX_1	0.3056
p.A844T	ACH-000943	Colon/Colorectal Cancer	CCLE	WREPLPAVD	DEG_APCC_DBOX_1	0.6028
p.A844T	RKO	large_intestine	COSMIC	WREPLPAVD	DEG_APCC_DBOX_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQK8	Phosphatidate phosphatase LPIN3	DEG_APCC_DBOX_1	838:846	WREPLPAVD	APC,CDC20,FZR1	0.8889	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons