DegronMD

Uniprot ID: Q96EA4

Source protein: Protein Spindly

Source gene: SPDL1

Class: DEG_SCF_FBW7_1

Location: 507:513

E3 ligase: FBXW7

DEGRON score: 0.9484

ASA_SCORE: 106.9857

COIL: 0.9144

CONS_SCORE: 0.3483

DSS_SCORE: 0.3404

HELIX: 0.0281

FCONS_SCORE: 0.9904

RIG_SCORE: 0.7679

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V522L	TCGA-64-5781	LUAD	TCGA	IYTPVVS	DEG_SCF_FBW7_1	0.0833
p.V522L	DO229031	LICA	ICGC	IYTPVVS	DEG_SCF_FBW7_1	0.0833
p.V522L	DO23740	LUAD	ICGC	IYTPVVS	DEG_SCF_FBW7_1	0.0833
p.V522M	TCGA-AA-3837	COAD	TCGA	IYTPVVS	DEG_SCF_FBW7_1	0.0833
p.V522M	DO10502	COAD	ICGC	IYTPVVS	DEG_SCF_FBW7_1	0.0833
p.D523N	TCGA-B5-A3FA	UCEC	TCGA	IYTPVVS	DEG_SCF_FBW7_1	0.0556
p.D523N	DO52402	UCEC	ICGC	IYTPVVS	DEG_SCF_FBW7_1	0.0556
p.P510Q	TCGA-BF-A1PU	SKCM	TCGA	IYTPVVS	DEG_SCF_FBW7_1	0.7035
p.P510Q	DO50278	SKCM	ICGC	IYTPVVS	DEG_SCF_FBW7_1	0.7035
p.S515C	TCGA-K4-A5RJ	BLCA	TCGA	IYTPVVS	DEG_SCF_FBW7_1	0.7222
p.S515C	DO48407	BLCA	ICGC	IYTPVVS	DEG_SCF_FBW7_1	0.7222
p.S515C	DO49784	BLCA	ICGC	IYTPVVS	DEG_SCF_FBW7_1	0.7222
p.Y508H	DO229010	COCA	ICGC	IYTPVVS	DEG_SCF_FBW7_1	0.6118
p.Y508H	DO229016	COCA	ICGC	IYTPVVS	DEG_SCF_FBW7_1	0.6118
p.Y508H	DO229003	COCA	ICGC	IYTPVVS	DEG_SCF_FBW7_1	0.6118
p.Y508H	DO229005	COCA	ICGC	IYTPVVS	DEG_SCF_FBW7_1	0.6118
p.V512F	DO229019	LICA	ICGC	IYTPVVS	DEG_SCF_FBW7_1	0.5957
p.L499F	DO229041	LICA	ICGC	IYTPVVS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96EA4	Protein Spindly	DEG_SCF_FBW7_1	507:513	IYTPVVS	FBXW7	0.9484	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons