DegronMD - Q96EA4(SPDL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V522L	TCGA-64-5781	LUAD	TCGA	IYTPVVS	DEG_SCF_FBW7_1	507:513	Mutation rewiring degron network	0.0833
p.V522L	DO229031	LICA	ICGC	IYTPVVS	DEG_SCF_FBW7_1	507:513	Mutation rewiring degron network	0.0833
p.V522L	DO23740	LUAD	ICGC	IYTPVVS	DEG_SCF_FBW7_1	507:513	Mutation rewiring degron network	0.0833
p.V522M	TCGA-AA-3837	COAD	TCGA	IYTPVVS	DEG_SCF_FBW7_1	507:513	Mutation rewiring degron network	0.0833
p.V522M	DO10502	COAD	ICGC	IYTPVVS	DEG_SCF_FBW7_1	507:513	Mutation rewiring degron network	0.0833
p.E445G	TCGA-AG-A002	READ	TCGA	LRAKLDELK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.0556
p.D432E	TCGA-AX-A0J0	UCEC	TCGA	LRAKLDELK	DEG_APCC_DBOX_1	427:435	Mutation altering degron motif	0.5647
p.D432E	DO41133	UCEC	ICGC	LRAKLDELK	DEG_APCC_DBOX_1	427:435	Mutation altering degron motif	0.5647
p.D523N	TCGA-B5-A3FA	UCEC	TCGA	IYTPVVS	DEG_SCF_FBW7_1	507:513	Mutation rewiring degron network	0.0556
p.D523N	DO52402	UCEC	ICGC	IYTPVVS	DEG_SCF_FBW7_1	507:513	Mutation rewiring degron network	0.0556
p.P510Q	TCGA-BF-A1PU	SKCM	TCGA	IYTPVVS	DEG_SCF_FBW7_1	507:513	Mutation altering degron motif	0.7035
p.P510Q	DO50278	SKCM	ICGC	IYTPVVS	DEG_SCF_FBW7_1	507:513	Mutation altering degron motif	0.7035
p.K437N	TCGA-CZ-5456	KIRC	TCGA	LRAKLDELK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.2778
p.E445K	TCGA-IR-A3LK	CESC	TCGA	LRAKLDELK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.0556
p.E445K	DO44299	CESC	ICGC	LRAKLDELK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.0556
p.S515C	TCGA-K4-A5RJ	BLCA	TCGA	IYTPVVS	DEG_SCF_FBW7_1	507:513	Mutation blocking phosphorylation signal	0.7222
p.S515C	DO48407	BLCA	ICGC	IYTPVVS	DEG_SCF_FBW7_1	507:513	Mutation blocking phosphorylation signal	0.7222
p.S515C	DO49784	BLCA	ICGC	IYTPVVS	DEG_SCF_FBW7_1	507:513	Mutation blocking phosphorylation signal	0.7222
p.T443I	TCGA-S9-A89V	LGG	TCGA	LRAKLDELK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1111
p.T443I	DO51840	LGG	ICGC	LRAKLDELK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1111
p.Y508H	DO229010	COCA	ICGC	IYTPVVS	DEG_SCF_FBW7_1	507:513	Mutation altering degron motif	0.6118
p.Y508H	DO229016	COCA	ICGC	IYTPVVS	DEG_SCF_FBW7_1	507:513	Mutation altering degron motif	0.6118
p.Y508H	DO229003	COCA	ICGC	IYTPVVS	DEG_SCF_FBW7_1	507:513	Mutation altering degron motif	0.6118
p.Y508H	DO229005	COCA	ICGC	IYTPVVS	DEG_SCF_FBW7_1	507:513	Mutation altering degron motif	0.6118
p.T443A	DO50396	ESAD	ICGC	LRAKLDELK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1111
p.Y438C	DO233944	GACA	ICGC	LRAKLDELK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.25
p.V512F	DO229019	LICA	ICGC	IYTPVVS	DEG_SCF_FBW7_1	507:513	Mutation altering degron motif	0.5957
p.L499F	DO229041	LICA	ICGC	IYTPVVS	DEG_SCF_FBW7_1	507:513	Mutation rewiring degron network	0.1111
p.A429P	DO231628	LINC	ICGC	LRAKLDELK	DEG_APCC_DBOX_1	427:435	Mutation altering degron motif	0.6392
p.L417P	DO229216	THCA	ICGC	LRAKLDELK	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.0556

Kaplan plot for SPDL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPDL1

UniProt ID: Q96EA4

Entrez ID: 54908

Protein name: Protein Spindly (hSpindly) (Arsenite-related gene 1 protein) (Coiled-coil domain-containing protein 99) (Rhabdomyosarcoma antigen MU-RMS-40.4A) (Spindle apparatus coiled-coil domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPDL1 in