DegronMD

Uniprot ID: Q96EA4

Source protein: Protein Spindly

Source gene: SPDL1

Class: DEG_APCC_DBOX_1

Location: 427:435

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8507

ASA_SCORE: 93.0889

COIL: 0.0486

CONS_SCORE: 0.6762

DSS_SCORE: 0.2645

HELIX: 0.9527

FCONS_SCORE: 1.2642

RIG_SCORE: 0.798

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A429P	DO231628	LINC	ICGC	LRAKLDELK	DEG_APCC_DBOX_1	0.6392
p.D432E	TCGA-AX-A0J0	UCEC	TCGA	LRAKLDELK	DEG_APCC_DBOX_1	0.5647
p.D432E	DO41133	UCEC	ICGC	LRAKLDELK	DEG_APCC_DBOX_1	0.5647
p.K437N	TCGA-CZ-5456	KIRC	TCGA	LRAKLDELK	DEG_APCC_DBOX_1	0.2778
p.Y438C	DO233944	GACA	ICGC	LRAKLDELK	DEG_APCC_DBOX_1	0.25
p.T443I	TCGA-S9-A89V	LGG	TCGA	LRAKLDELK	DEG_APCC_DBOX_1	0.1111
p.T443I	DO51840	LGG	ICGC	LRAKLDELK	DEG_APCC_DBOX_1	0.1111
p.T443A	DO50396	ESAD	ICGC	LRAKLDELK	DEG_APCC_DBOX_1	0.1111
p.E445G	TCGA-AG-A002	READ	TCGA	LRAKLDELK	DEG_APCC_DBOX_1	0.0556
p.E445K	TCGA-IR-A3LK	CESC	TCGA	LRAKLDELK	DEG_APCC_DBOX_1	0.0556
p.E445K	DO44299	CESC	ICGC	LRAKLDELK	DEG_APCC_DBOX_1	0.0556
p.L417P	DO229216	THCA	ICGC	LRAKLDELK	DEG_APCC_DBOX_1	0.0556

Showing 1 to 12 of 12 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96EA4	Protein Spindly	DEG_APCC_DBOX_1	427:435	LRAKLDELK	APC,CDC20,FZR1	0.8507	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons