DegronMD

Uniprot ID: Q96F86

Source protein: Enhancer of mRNA-decapping protein 3

Source gene: EDC3

Class: LIG_APCC_ABBAyCdc20_2

Location: 215:221

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5437

ASA_SCORE: 76.8286

COIL: 0.3699

CONS_SCORE: 0.6084

DSS_SCORE: 0.2741

HELIX: 0.5846

FCONS_SCORE: 1.0689

RIG_SCORE: 0.8632

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A211T	TCGA-AX-A1CE	UCEC	TCGA	KAAVFEE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A211T	DO42280	UCEC	ICGC	KAAVFEE	LIG_APCC_ABBAyCdc20_2	0.2222
p.I222V	TCGA-BH-A0WA	BRCA	TCGA	KAAVFEE	LIG_APCC_ABBAyCdc20_2	0.3056
p.I222V	DO2897	BRCA	ICGC	KAAVFEE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D205H	TCGA-D8-A1JA	BRCA	TCGA	KAAVFEE	LIG_APCC_ABBAyCdc20_2	0.0556
p.D205H	DO2819	BRCA	ICGC	KAAVFEE	LIG_APCC_ABBAyCdc20_2	0.0556
p.G208R	TCGA-DS-A0VM	CESC	TCGA	KAAVFEE	LIG_APCC_ABBAyCdc20_2	0.1389
p.G208R	DO6258	CESC	ICGC	KAAVFEE	LIG_APCC_ABBAyCdc20_2	0.1389
p.N209D	TCGA-EO-A3B0	UCEC	TCGA	KAAVFEE	LIG_APCC_ABBAyCdc20_2	0.1667
p.N209D	DO219773	UCEC	ICGC	KAAVFEE	LIG_APCC_ABBAyCdc20_2	0.1667
p.T224N	DO229028	LICA	ICGC	KAAVFEE	LIG_APCC_ABBAyCdc20_2	0.6944
p.S229N	DO229177	LMS	ICGC	KAAVFEE	LIG_APCC_ABBAyCdc20_2	0.1111
p.L210M	DO232224	PBCA	ICGC	KAAVFEE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G208E	ACH-000127	Bladder Cancer	CCLE	KAAVFEE	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96F86	Enhancer of mRNA-decapping protein 3	LIG_APCC_ABBAyCdc20_2	215:221	KAAVFEE	APC,CDC20,FZR1	0.5437	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons