DegronMD - Q96F86(EDC3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q97H	TCGA-34-8454	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	107:111	Mutation rewiring degron network	0.0556
p.Q97H	DO50094	LUSC	ICGC	PASSS	DEG_SPOP_SBC_1	107:111	Mutation rewiring degron network	0.0556
p.Y284H	TCGA-4R-AA8I	LIHC	TCGA	TDSGLVVPSI	DEG_COP1_1	273:282	Mutation rewiring degron network	0.2778
p.Y284H	DO49657	LIHC	ICGC	TDSGLVVPSI	DEG_COP1_1	273:282	Mutation rewiring degron network	0.2778
p.A211T	TCGA-AX-A1CE	UCEC	TCGA	KAAVFEE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.2222
p.A211T	DO42280	UCEC	ICGC	KAAVFEE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.2222
p.Q115L	TCGA-B5-A1MX	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	107:111	Mutation rewiring degron network	0.2222
p.Q115L	DO41999	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	107:111	Mutation rewiring degron network	0.2222
p.I222V	TCGA-BH-A0WA	BRCA	TCGA	KAAVFEE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.3056
p.I222V	DO2897	BRCA	ICGC	KAAVFEE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.3056
p.Q115E	TCGA-C5-A1BK	CESC	TCGA	PASSS	DEG_SPOP_SBC_1	107:111	Mutation rewiring degron network	0.2222
p.Q115E	DO6266	CESC	ICGC	PASSS	DEG_SPOP_SBC_1	107:111	Mutation rewiring degron network	0.2222
p.D205H	TCGA-D8-A1JA	BRCA	TCGA	KAAVFEE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.0556
p.D205H	DO2819	BRCA	ICGC	KAAVFEE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.0556
p.G208R	TCGA-DS-A0VM	CESC	TCGA	KAAVFEE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.1389
p.G208R	DO6258	CESC	ICGC	KAAVFEE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.1389
p.N209D	TCGA-EO-A3B0	UCEC	TCGA	KAAVFEE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.1667
p.N209D	DO219773	UCEC	ICGC	KAAVFEE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.1667
p.Q97K	DO218065	BRCA	ICGC	PASSS	DEG_SPOP_SBC_1	107:111	Mutation rewiring degron network	0.0556
p.T224N	DO229028	LICA	ICGC	KAAVFEE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation blocking phosphorylation signal	0.6944
p.P264T	DO229031	LICA	ICGC	TDSGLVVPSI	DEG_COP1_1	273:282	Mutation rewiring degron network	0.0833
p.S229N	DO229177	LMS	ICGC	KAAVFEE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.1111
p.L210M	DO232224	PBCA	ICGC	KAAVFEE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.1944
p.F271L	DO229268	THCA	ICGC	TDSGLVVPSI	DEG_COP1_1	273:282	Mutation rewiring degron network	0.2778
p.V267M	SIDM01237	Hepatocellular Carcinoma	GDSC	TDSGLVVPSI	DEG_COP1_1	273:282	Mutation rewiring degron network	0.1667
p.V267M	SIDM00594	Acute Myeloid Leukemia	GDSC	TDSGLVVPSI	DEG_COP1_1	273:282	Mutation rewiring degron network	0.1667
p.V267M	SIDM01206	Neuroblastoma	GDSC	TDSGLVVPSI	DEG_COP1_1	273:282	Mutation rewiring degron network	0.1667
p.V267M	SIDM00049	Colorectal Carcinoma	GDSC	TDSGLVVPSI	DEG_COP1_1	273:282	Mutation rewiring degron network	0.1667
p.G208E	ACH-000127	Bladder Cancer	CCLE	KAAVFEE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.1389

Kaplan plot for EDC3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EDC3

UniProt ID: Q96F86

Entrez ID: 80153

Protein name: Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EDC3 in