DegronMD

Uniprot ID: Q96F86

Source protein: Enhancer of mRNA-decapping protein 3

Source gene: EDC3

Class: DEG_COP1_1

Location: 273:282

E3 ligase: COP1

DEGRON score: 0.9059

ASA_SCORE: 50.91

COIL: 0.7614

CONS_SCORE: 0.555

DSS_SCORE: 0.1293

HELIX: 0.0489

FCONS_SCORE: 1.3052

RIG_SCORE: 0.8111

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y284H	TCGA-4R-AA8I	LIHC	TCGA	TDSGLVVPSI	DEG_COP1_1	0.2778
p.Y284H	DO49657	LIHC	ICGC	TDSGLVVPSI	DEG_COP1_1	0.2778
p.P264T	DO229031	LICA	ICGC	TDSGLVVPSI	DEG_COP1_1	0.0833
p.F271L	DO229268	THCA	ICGC	TDSGLVVPSI	DEG_COP1_1	0.2778
p.V267M	SIDM01237	Hepatocellular Carcinoma	GDSC	TDSGLVVPSI	DEG_COP1_1	0.1667
p.V267M	SIDM00594	Acute Myeloid Leukemia	GDSC	TDSGLVVPSI	DEG_COP1_1	0.1667
p.V267M	SIDM01206	Neuroblastoma	GDSC	TDSGLVVPSI	DEG_COP1_1	0.1667
p.V267M	SIDM00049	Colorectal Carcinoma	GDSC	TDSGLVVPSI	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96F86	Enhancer of mRNA-decapping protein 3	DEG_COP1_1	273:282	TDSGLVVPSI	COP1	0.9059	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons