DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
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Degron:
KDIMHPE
Uniprot ID:
Q8NDH2
Source protein:
Leucine-rich repeat transmembrane protein CCDC168
Source gene:
CCDC168
Class:
LIG_APCC_ABBAyCdc20_2
Location:
4166:4172
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6485
ASA_SCORE:
105.0143
COIL:
0.8193
CONS_SCORE:
0
DSS_SCORE:
0.5175
HELIX:
0.0656
FCONS_SCORE:
0
RIG_SCORE:
0.711
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CCDC168 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KDIMHPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NDH2
Leucine-rich repeat transmembrane protein CCDC168
LIG_APCC_ABBAyCdc20_2
4166:4172
KDIMHPE
APC,CDC20,FZR1
0.6485
More...