DegronMD

Uniprot ID: Q8IW52

Source protein: SLIT and NTRK-like protein 4

Source gene: SLITRK4

Class: LIG_APCC_ABBAyCdc20_2

Location: 729:735

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6719

ASA_SCORE: 82.1714

COIL: 0.5576

CONS_SCORE: 0.3784

DSS_SCORE: 0.3193

HELIX: 0.3847

FCONS_SCORE: 1.0095

RIG_SCORE: 0.8244

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D735H	SIDM01590	Breast Carcinoma	GDSC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.7688
p.D735H	ACH-000184	Non-Cancerous	CCLE	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.7688
p.K729N	DO228621	GACA	ICGC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.6918
p.E728K	TCGA-BF-AAP4	SKCM	TCGA	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E728K	DO219468	SKCM	ICGC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.3056
p.D726E	TCGA-78-7155	LUAD	TCGA	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.25
p.D726E	DO23590	LUAD	ICGC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.25
p.D726E	SIDM00630	Breast Carcinoma	GDSC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.25
p.D726E	SIDM01228	Melanoma	GDSC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.25
p.D726E	CHL-1	skin	COSMIC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.25
p.D726E	MDA-MB-415	breast	COSMIC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.25
p.D726N	TCGA-AP-A0LM	UCEC	TCGA	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.25
p.D726N	TCGA-EY-A1GV	UCEC	TCGA	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.25
p.D726N	DO43306	UCEC	ICGC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.25
p.D726N	DO42785	UCEC	ICGC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.25
p.A725V	ACH-000773	Lymphoma	CCLE	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.2222
p.A725S	ACH-000773	Lymphoma	CCLE	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.2222
p.V724L	DO50842	LIRI	ICGC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.1944
p.V724A	DO231419	THCA	ICGC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R722I	TCGA-DK-A6AW	BLCA	TCGA	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R722I	DO48566	BLCA	ICGC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.1389
p.V720A	TCGA-14-0866	GBM	TCGA	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.0833
p.V720A	DO11878	GBM	ICGC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.0833
p.E745K	TCGA-PE-A5DE	BRCA	TCGA	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.0556
p.E745K	DO219643	BRCA	ICGC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	0.0556

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Drug responses associated with SLITRK4 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of KDLLHVD

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IW52	SLIT and NTRK-like protein 4	LIG_APCC_ABBAyCdc20_2	729:735	KDLLHVD	APC,CDC20,FZR1	0.6719	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KDLLHVD

Degron related mutations and impact score

Drug responses associated with SLITRK4 mutations

All proteins holding degron of KDLLHVD