DegronMD - Q8IW52(SLITRK4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V720A	TCGA-14-0866	GBM	TCGA	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation rewiring degron network	0.0833
p.V720A	DO11878	GBM	ICGC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation rewiring degron network	0.0833
p.D754G	TCGA-50-5935	LUAD	TCGA	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.0556
p.D754G	DO23588	LUAD	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.0556
p.D726E	TCGA-78-7155	LUAD	TCGA	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.0556
p.D726E	TCGA-78-7155	LUAD	TCGA	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation rewiring degron network	0.25
p.D726E	DO23590	LUAD	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.0556
p.D726E	DO23590	LUAD	ICGC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation rewiring degron network	0.25
p.D726E	SIDM00630	Breast Carcinoma	GDSC	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.0556
p.D726E	SIDM00630	Breast Carcinoma	GDSC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation rewiring degron network	0.25
p.D726E	SIDM01228	Melanoma	GDSC	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.0556
p.D726E	SIDM01228	Melanoma	GDSC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation rewiring degron network	0.25
p.D726E	CHL-1	skin	COSMIC	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.0556
p.D726E	CHL-1	skin	COSMIC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation rewiring degron network	0.25
p.D726E	MDA-MB-415	breast	COSMIC	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.0556
p.D726E	MDA-MB-415	breast	COSMIC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation rewiring degron network	0.25
p.T736N	TCGA-AP-A051	UCEC	TCGA	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.7055
p.T736N	DO42673	UCEC	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.7055
p.T736N	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.7055
p.T736N	ACH-000510	Lung Cancer	CCLE	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.7055
p.T736N	NCI-H1299	lung	COSMIC	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.7055
p.K738N	TCGA-AP-A056	UCEC	TCGA	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.5806
p.K738N	DO43971	UCEC	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.5806
p.D726N	TCGA-AP-A0LM	UCEC	TCGA	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.0556
p.D726N	TCGA-AP-A0LM	UCEC	TCGA	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation rewiring degron network	0.25
p.D726N	TCGA-EY-A1GV	UCEC	TCGA	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.0556
p.D726N	TCGA-EY-A1GV	UCEC	TCGA	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation rewiring degron network	0.25
p.D726N	DO43306	UCEC	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.0556
p.D726N	DO43306	UCEC	ICGC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation rewiring degron network	0.25
p.D726N	DO42785	UCEC	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.0556
p.D726N	DO42785	UCEC	ICGC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation rewiring degron network	0.25
p.S741I	TCGA-AP-A1DV	UCEC	TCGA	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.7341
p.S741I	DO43186	UCEC	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.7341
p.E728K	TCGA-BF-AAP4	SKCM	TCGA	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1111
p.E728K	TCGA-BF-AAP4	SKCM	TCGA	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation rewiring degron network	0.3056
p.E728K	DO219468	SKCM	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1111
p.E728K	DO219468	SKCM	ICGC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation rewiring degron network	0.3056
p.R722I	TCGA-DK-A6AW	BLCA	TCGA	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation rewiring degron network	0.1389
p.R722I	DO48566	BLCA	ICGC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation rewiring degron network	0.1389
p.P751S	TCGA-GN-A266	SKCM	TCGA	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1389
p.P751S	DO37432	SKCM	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1389
p.E745K	TCGA-PE-A5DE	BRCA	TCGA	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.3056
p.E745K	TCGA-PE-A5DE	BRCA	TCGA	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation rewiring degron network	0.0556
p.E745K	DO219643	BRCA	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.3056
p.E745K	DO219643	BRCA	ICGC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation rewiring degron network	0.0556
p.D754N	TCGA-W3-AA21	SKCM	TCGA	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.0556
p.D754N	DO51278	SKCM	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.0556
p.K729N	DO228621	GACA	ICGC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation altering degron motif	0.6918
p.V724L	DO50842	LIRI	ICGC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation rewiring degron network	0.1944
p.L749F	DO220851	MELA	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1944
p.V724A	DO231419	THCA	ICGC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation rewiring degron network	0.1944
p.D735H	SIDM01590	Breast Carcinoma	GDSC	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation altering degron motif	0.7688
p.D735H	ACH-000184	Non-Cancerous	CCLE	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation altering degron motif	0.7688
p.A725V	ACH-000773	Lymphoma	CCLE	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation rewiring degron network	0.2222
p.A725S	ACH-000773	Lymphoma	CCLE	KDLLHVD	LIG_APCC_ABBAyCdc20_2	729:735	Mutation rewiring degron network	0.2222
p.L749I	ACH-002002	Skin Cancer	CCLE	TRKRLSTID	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLITRK4

UniProt ID: Q8IW52

Entrez ID: 139065

Protein name: SLIT and NTRK-like protein 4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLITRK4 in