DegronMD

Uniprot ID: Q8IW52

Source protein: SLIT and NTRK-like protein 4

Source gene: SLITRK4

Class: DEG_APCC_DBOX_1

Location: 736:744

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5571

ASA_SCORE: 82.3333

COIL: 0.6257

CONS_SCORE: 0.4156

DSS_SCORE: 0.238

HELIX: 0.1508

FCONS_SCORE: 1.0628

RIG_SCORE: 0.8075

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D754G	TCGA-50-5935	LUAD	TCGA	TRKRLSTID	DEG_APCC_DBOX_1	0.0556
p.D754G	DO23588	LUAD	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	0.0556
p.D726E	TCGA-78-7155	LUAD	TCGA	TRKRLSTID	DEG_APCC_DBOX_1	0.0556
p.D726E	DO23590	LUAD	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	0.0556
p.D726E	SIDM00630	Breast Carcinoma	GDSC	TRKRLSTID	DEG_APCC_DBOX_1	0.0556
p.D726E	SIDM01228	Melanoma	GDSC	TRKRLSTID	DEG_APCC_DBOX_1	0.0556
p.D726E	CHL-1	skin	COSMIC	TRKRLSTID	DEG_APCC_DBOX_1	0.0556
p.D726E	MDA-MB-415	breast	COSMIC	TRKRLSTID	DEG_APCC_DBOX_1	0.0556
p.T736N	TCGA-AP-A051	UCEC	TCGA	TRKRLSTID	DEG_APCC_DBOX_1	0.7055
p.T736N	DO42673	UCEC	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	0.7055
p.T736N	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	TRKRLSTID	DEG_APCC_DBOX_1	0.7055
p.T736N	ACH-000510	Lung Cancer	CCLE	TRKRLSTID	DEG_APCC_DBOX_1	0.7055
p.T736N	NCI-H1299	lung	COSMIC	TRKRLSTID	DEG_APCC_DBOX_1	0.7055
p.K738N	TCGA-AP-A056	UCEC	TCGA	TRKRLSTID	DEG_APCC_DBOX_1	0.5806
p.K738N	DO43971	UCEC	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	0.5806
p.D726N	TCGA-AP-A0LM	UCEC	TCGA	TRKRLSTID	DEG_APCC_DBOX_1	0.0556
p.D726N	TCGA-EY-A1GV	UCEC	TCGA	TRKRLSTID	DEG_APCC_DBOX_1	0.0556
p.D726N	DO43306	UCEC	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	0.0556
p.D726N	DO42785	UCEC	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	0.0556
p.S741I	TCGA-AP-A1DV	UCEC	TCGA	TRKRLSTID	DEG_APCC_DBOX_1	0.7341
p.S741I	DO43186	UCEC	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	0.7341
p.E728K	TCGA-BF-AAP4	SKCM	TCGA	TRKRLSTID	DEG_APCC_DBOX_1	0.1111
p.E728K	DO219468	SKCM	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	0.1111
p.P751S	TCGA-GN-A266	SKCM	TCGA	TRKRLSTID	DEG_APCC_DBOX_1	0.1389
p.P751S	DO37432	SKCM	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	0.1389
p.E745K	TCGA-PE-A5DE	BRCA	TCGA	TRKRLSTID	DEG_APCC_DBOX_1	0.3056
p.E745K	DO219643	BRCA	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	0.3056
p.D754N	TCGA-W3-AA21	SKCM	TCGA	TRKRLSTID	DEG_APCC_DBOX_1	0.0556
p.D754N	DO51278	SKCM	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	0.0556
p.L749F	DO220851	MELA	ICGC	TRKRLSTID	DEG_APCC_DBOX_1	0.1944
p.L749I	ACH-002002	Skin Cancer	CCLE	TRKRLSTID	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRKRLSTID

Degron related mutations and impact score

Drug responses associated with SLITRK4 mutations

All proteins holding degron of TRKRLSTID

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IW52	SLIT and NTRK-like protein 4	DEG_APCC_DBOX_1	736:744	TRKRLSTID	APC,CDC20,FZR1	0.5571	More...